Drug of Abuse Flashcards
Types of Opiods
- OPIUM
- HEROIN
- OXYCODONE
- MEPERIDINE
Types of SEDATIVE - HYPNOTICS
- BENZODIAZEPINES
- BARBITURATES
- ALCOHOL
- GAMMA HYDROXYBUTYRIC ACID
Types of CANNABINOIDS
MARIJUANA
Types of HALLUCINOGENS
- LSD
- MESCALINE
- PSILOCYBIN
- KETAMINE
- PHENCYCLIDINE
- SCOPOLAMINE
OTHER DRUGS OF ABUSE
- COCAINE
- AMPHETAMINES
- ECSTASY
- ANABOLIC STEROIDS
Types of STIMULANTS
- NICOTINE
- CAFFEINE
- INHALANTS
Types of INHALANTS
- ANESTHETICS
- INDUSTRIAL SOLVENTS
- ORGANIC NITRITES
Papaver somniferum
Opium
powerful narcotic, painkiller
Opium
principal active ingredient is MORPHINE
Opium
insomnia, hallucination,
nightmares
Opium
histamine release
Opium
SC, IV
Opium
more pronounced
effects than heroin
Opium
Smack, H, ska, junk
Heroin
diamorphine
HEROIN
an addictive drug as a white or brown powder
HEROIN
tends to be used with other drugs
HEROIN
fast-acting
HEROIN
IV
Heroin
T1/2= 3-5 hrs, therefore several doses/ day
HEROIN
Withdrawal 5-10 hrs after
HEROIN
synthesized from thebaine
Oxycodone
derived from codeine
Oxycodone
tablet or oral form
Oxycodone
increasingly popular
Oxycodone
pethidine
Meperidine
Demerol
Meperidine
serious interaction with MAO’s
Meperidine
attempts to illicitly produce this
has resulted in MPTP which can cause parkinsonism
Meperidine
MPTP: methyl-phenyl-tetrahydropyridine
Meperidine
can be short- to long- acting
Sedative - hypnotics
the longer the duration the less the withdrawal
Sedative - hypnotics
anxiety, tremors, twitches, vomiting
Sedative - hypnotics
rare occurrence of physiologic dependence
Benzodiazepines
weight loss, change in perception, paresthesia, headache
“Therapeutic Dose Dependence”
Benzodiazepines
Flunitrazepam
Benzodiazepines
“Therapeutic Dose Dependence”
Benzodiazepines
used for date rape
Flunitrazepam
Benzodiazepines
Rohypnol
Benzodiazepines
brand name for the drug flunitrazepam
Rohypnol
Benzodiazepines
roofies (1mg tab)
Rohypnol
Benzodiazepines
anterograde amnesia
Flunitrazepam
Benzodiazepines
Schedule IV
Flunitrazepam
Benzodiazepines
anterograde amnesia
Flunitrazepam
Benzodiazepines
GABAa receptors
Barbiturates
usually Short- acting drugs
Barbiturates
eg. Secobarbital, pentobarbital Na
Barbiturates
not used as much as other drugs
Barbiturates
euphoria
- Alcohol
- LSD
- Gamma Hydroxybutyric Acid
- Marijuana
- Anesthetics
- Industrial solvents
Alcoholism
Alcohol
Affect GABAa and NMDA
Alcohol
withdrawal: motor agitation, anxiety, insomnia, hallucination, abnormal vital signs, seizures
Alcohol
GABAb
Gamma Hydroxybutyric Acid
naturally found in body
Gamma Hydroxybutyric Acid
can be found in fermented drinks like guava
(Psidium guajava)
Gamma Hydroxybutyric Acid
euphoric, sedative, anabolic
Gamma Hydroxybutyric Acid
widely sold until 1992
Gamma Hydroxybutyric Acid
liquid ecstasy, soap, easy lay, vita-G
Gamma Hydroxybutyric Acid
Georgia homeboy
Gamma Hydroxybutyric Acid
use with alcohol can produce breathing
problems
Gamma Hydroxybutyric Acid
withdrawal effects include: insomnia, anxiety, tremors, sweating
Gamma Hydroxybutyric Acid
Treatment for Short acting and Long acting drugs:
chlordiazepoxide or phenobarbital
Treatment for alcohol
disulfiram, naltrexone
Cannabis sativa
Marijuana
cannabinol, tetrahydrocannabinol, cannabidiol
Marijuana
cannabinoid receptors (CB1)
Marijuana
smoked
Marijuana
effects in 2-3 inhalations
Marijuana
“high,” euphoria, laughter, relaxation
Marijuana
Schedule I
Marijuana
antiemetic
Marijuana
tolerance
Marijuana
uncertain effect on fetus
Marijuana
Amotivational syndrome
Marijuana
diseases related to smoking
Marijuana
Dronabinol
Marijuana
Chemotheraphy Px
Nabilone
Marijuana
Mutiple Sclerosis
Nabiximol
Marijuana
Lysergic acid diethylamide
LSD
Claviceps purpurea
LSD
synthetic agent related to ergot alkaloids
LSD
NE, dopamine, serotonin
LSD
5-HT1a & 5-HT1c agonists
LSD
one of the most potent drugs 1ug/kg
LSD
absence of known fatalities
LSD
duration based on dose
LSD
waxing and waning effects
LSD
rise in body temp
LSD
uterine contractions
LSD
elevated sugar levels
LSD
goosebumps
LSD
pupil dilation
LSD
Lophophora williamsii
Mescaline
restricted but allowed
occasionally to North American Indians
Mescaline
5-6mg/kg
Mescaline
Psilocybe mushroom
Psilocybin
250ug/kg
Psilocybin
mydriasis, muscle relaxation, dizziness
Psilocybin
anesthetic
Ketamine
“special K” “vitamin K”
Ketamine
dream-like states
Ketamine
hallucination
- Ketamine
- LSD
- Opium
- Alcohol
- Inhalants
delirium
Ketamine
amnesia
Ketamine
high BP
Ketamine
depression
Ketamine
fatal respiratory
problems
Ketamine
angel dust, PCP
Phencyclidine
phenylcyclohexamine deriv
Phencyclidine
veterinary anesthetic
Phencyclidine
smoked with tobacco, snorted, Oral, IV
Phencyclidine
antagonize NMDA
Phencyclidine
animals will self administer it
Phencyclidine
Olney’s lesions
Phencyclidine
long t1/2
Phencyclidine
users tend to be violent
and suicidal
Phencyclidine
“bad-trips”
Phencyclidine
Hyoscyamus niger
Scopolamine
block central muscarinic receptors
Scopolamine
unpleasant to users
Scopolamine
same effects as other hallucinogens
Scopolamine
Erythroxylon coca
Coccaine
dopaminergic reuptake
transmitter
Coccaine
inhibit reuptake of
dopamine and NE
Coccaine
free base is absorbed
as fast as IV
Coccaine
t1/2= 1hr, repeated
30min
Coccaine
symptoms include a
feeling of bugs
under skin
Coccaine
paranoia and
schizophrenia like state
Coccaine
exhaustion by lack of
sleep and food
Coccaine
appetite, exhaustion,
depression
Coccaine
alpha-methyl-phenethylamine
Amphetamines
increase catecholinergic neurotransmitters
Amphetamines
dopamine not be metabolized thus released
Amphetamines
treat narcolepsy and ADHD
Amphetamines
paranoid psychosis
Amphetamines
necrotizing arteritis
Amphetamines
OD is rarely fatal
Amphetamines
managed by benzodiazepines
Amphetamines
Schedule II
Amphetamines
decreased appetite, inc. stamina, energy
sexual drive
Amphetamines
loss of REM sleep, tremor, restlessness,
anxiety,
Amphetamines
related drugs (shabu, ecstasy)
Amphetamines
Methylene-dioxymethamphetamine (MDMA)
Ecstacy
intimacy and empathy
Ecstacy
“raves” designer drug
Ecstacy
SERT
Ecstacy
“uppers,”
Stimulants
reverse the effects of fatigue on both mental and
physical tasks.
Stimulants
coffee, tea, some soft drinks, and many
non-prescription medicines
Caffeine
tobacco products
Nicotine
Nicotiana tobacum
Nicotine
nicotinic cholinergic receptor agonist
Nicotine
1 drop is fatal
Nicotine
strong psychological and physiological dependence (more addictive than heroin and cocaine)
Nicotine
Including dopamine
Nicotine
SIDS, carcinogenic
Nicotine
1,3,7-trimethylxanthine
Caffeine
xanthine alkaloid from Coffea arabica
Caffeine
adenosine receptors
Caffeine
low chance of abuse and addiction
Caffeine
5 cups/ day
Caffeine
anesthetic gases
Inhalants
industrial solvents
Inhalants
Inhalants
aerosol propellants
Inhalants
organic nitrites
Inhalants
psychoactive effects
Inhalants
alcohol-like intoxications,
hallucinations,
Inhalants
hypoxia, pneumonia,
cardiac fauilure
Inhalants
headache, nausea, vomiting, slurred speech, loss of motor coordination, wheezing
Inhalants
difficulty in concentrating, dreaminess,
euphoria, numbness, tingling
Anesthetics
N2O= 35% used; 100% death
Anesthetics
ether & chloroform
Anesthetics
gasoline, toluene,
benzene, trichloro-ethylene
Industrial solvents
5-15min
Industrial solvents
euphoria, “drunk” feeling,
disorientation
Industrial solvents
slow passage of time
Industrial solvents
Eg. Glue, correction fluid,
gas
Industrial solvents
amyl nitrite, isobutyl nitrite
Organic nitrites
dizziness, rapid heart rate, lowered BP,
“speeding,” flushing of skin
Organic nitrites
enhance, prolong erection
Organic nitrites
Liver, kidney, peripheral nerve, and brain
damage
Organic nitrites
Bone marrow suspension
Organic nitrites
Pulmonary disease
Organic nitrites
Death
Organic nitrites
cyclopentanoperhydrophenanthrene ring
Anabolic Steroids
bone growth, appetite, puberty, muscle
growth
Anabolic Steroids
Schedule III
Anabolic Steroids
change in libido, irritability, violence, mood
swings, forgetfulness, confusion
Anabolic Steroids
fatigue, depressed mood, craving for steroids
Anabolic Steroids
hypertrophied muscles,
acne, oily skin, hirsutism in females, gynecomastia in
males, needle punctures
Anabolic Steroids
high LDL; low HDL
Anabolic Steroids
elevated liver function
Anabolic Steroids