Protein Synthesis Inhibitors

Question 1

What class change the shape of the 30s subunit

Answer 1

Aminoglycosides

Question 2

Oldest Aminoglycoside

Answer 2

Streptomycin

Question 3

Most commonly used Aminoglycoside

Answer 3

Gentamycin

Question 4

Broadest Spectrum Aminoglycoside

Answer 4

Amikacin

Question 5

Aminoglycoside for Pseudomonas

Answer 5

Tobramycin

Question 6

Topical Aminoglycoside

Answer 6

Neomycin

Question 7

Aminoglycosides treat what type of microbe

Answer 7

aerobic Gram - bacteria

Question 8

What is true affect of aminoglycosides on microbes and how are they doesed

Answer 8

once daily and are bactericidal

Question 9

What Aminoglycoside crosses the blood brain barrier and how does it do i

Answer 9

Overdoes of neimycin

Question 10

most prevalent side affect of Aminoglycosises

Answer 10

nephrotoxity and otitoxi

Question 11

What microbes are affected by tetracycline

Answer 11

Gram +/-, and atypical intracellular

Question 12

What class block the aminoacyl-trna from the a site

Answer 12

Tetracycline

Question 13

Side effects of tetraclyclines

Answer 13

GI upset
Hepatotoxicicty
Disulfuram-like effect
Superunfections
Oral problems

Question 14

What tetraacline drug addresses TTC resistance and broadens the spectrum to what?

Answer 14

Tigecycline

MRSA, MDR Step, VRE and some anaerobes

Question 15

What class binds the 50s subunit irreversibly and what affect to they exert

Answer 15

Macrolides/Ketolides and Clindamycin

bacteriostatirc

Question 16

What spectrum do Macrolides have

Answer 16

gram +/- and atypical bacteria.

Have cross resistance within class

Question 17

When are Macrolides used

Answer 17

Very safe and used for URI, community acquired pneumonia and second line for skin infections

Question 18

When is Erythromycin used and for what type of bacteria

Answer 18

When allergic to penicillin for gram +, spitochetes and gonorrhea.

Question 19

What is the difference between Clarithomycin and erythromycin

Answer 19

Calri adds H influenza and H pylori

Question 20

Why use Azithromycin?

Answer 20

Longest half-life and more effective on URIs due to h influenza or mycobacterium as well aurethra from chlamyur

Question 21

What class inhibits 50s peptidyltransferase?

Answer 21

Chloramphenicol

Question 22

what is the spectrum of Chloramphenicol and what are its risks

Answer 22

Gram +/-, anaerobes
only used in the hospital
severely toxic
crosses blood brain barrier
teratogenic
hemolytic and a plastic anemia

Question 23

What two classes should not be used together

Answer 23

macrolides and clindamycin

Question 24

What is the spectrum of Clindamycin

Answer 24

Anaerobes and non-enterococcal gram+ cocci

NO effect on gram-

Question 25

What is Clindimycin often paired with for deep infections

Answer 25

Aminoglycosides (takes care of gram -)

Question 26

What is the class that inhibits the formation of the 70s complex

Answer 26

Linezolid

Question 27

What is the spectrum of Linezolid and when is it used

Answer 27

gram +
MRSA
VRE
Xommunity

Question 28

What are the size effects of Linezolid

Answer 28

Rare but-
Bone marrow suppression
headache and GI upset
Reversible neurotoxicity
SSRI complications

Question 29

What class of drugs is a combo of 2 druges

Answer 29

Streptogramins (Quinuprostin/Dalfopristin)

Question 30

What is the spectrum of Streptogramins

Answer 30

Gram + cocci

inactive to all gram - besides Moraxella and neisseria

Question 31

When to use Streptogramins

Answer 31

Reserved for multidrug resistant gram +

Question 32

What class reverisbly inhibits isoleucyl transfer RNA sythetase enzyme

Answer 32

Mupirocin

Question 33

when to use Mupirocin

Answer 33

Gram +/- skin infections