Protein Synthesis Inhibitors Flashcards
What class change the shape of the 30s subunit
Aminoglycosides
Oldest Aminoglycoside
Streptomycin
Most commonly used Aminoglycoside
Gentamycin
Broadest Spectrum Aminoglycoside
Amikacin
Aminoglycoside for Pseudomonas
Tobramycin
Topical Aminoglycoside
Neomycin
Aminoglycosides treat what type of microbe
aerobic Gram - bacteria
What is true affect of aminoglycosides on microbes and how are they doesed
once daily and are bactericidal
What Aminoglycoside crosses the blood brain barrier and how does it do i
Overdoes of neimycin
most prevalent side affect of Aminoglycosises
nephrotoxity and otitoxi
What microbes are affected by tetracycline
Gram +/-, and atypical intracellular
What class block the aminoacyl-trna from the a site
Tetracycline
Side effects of tetraclyclines
GI upset Hepatotoxicicty Disulfuram-like effect Superunfections Oral problems
What tetraacline drug addresses TTC resistance and broadens the spectrum to what?
Tigecycline
MRSA, MDR Step, VRE and some anaerobes
What class binds the 50s subunit irreversibly and what affect to they exert
Macrolides/Ketolides and Clindamycin
bacteriostatirc
What spectrum do Macrolides have
gram +/- and atypical bacteria.
Have cross resistance within class
When are Macrolides used
Very safe and used for URI, community acquired pneumonia and second line for skin infections
When is Erythromycin used and for what type of bacteria
When allergic to penicillin for gram +, spitochetes and gonorrhea.
What is the difference between Clarithomycin and erythromycin
Calri adds H influenza and H pylori
Why use Azithromycin?
Longest half-life and more effective on URIs due to h influenza or mycobacterium as well aurethra from chlamyur
What class inhibits 50s peptidyltransferase?
Chloramphenicol
what is the spectrum of Chloramphenicol and what are its risks
Gram +/-, anaerobes only used in the hospital severely toxic crosses blood brain barrier teratogenic hemolytic and a plastic anemia
What two classes should not be used together
macrolides and clindamycin
What is the spectrum of Clindamycin
Anaerobes and non-enterococcal gram+ cocci
NO effect on gram-
What is Clindimycin often paired with for deep infections
Aminoglycosides (takes care of gram -)
What is the class that inhibits the formation of the 70s complex
Linezolid
What is the spectrum of Linezolid and when is it used
gram +
MRSA
VRE
Xommunity
What are the size effects of Linezolid
Rare but- Bone marrow suppression headache and GI upset Reversible neurotoxicity SSRI complications
What class of drugs is a combo of 2 druges
Streptogramins (Quinuprostin/Dalfopristin)
What is the spectrum of Streptogramins
Gram + cocci
inactive to all gram - besides Moraxella and neisseria
When to use Streptogramins
Reserved for multidrug resistant gram +
What class reverisbly inhibits isoleucyl transfer RNA sythetase enzyme
Mupirocin
when to use Mupirocin
Gram +/- skin infections
