Folate Synthesis Inhibitors

Question 1

What intermediate do Sulfonamides impersonate

Answer 1

PABA

Question 2

What type of bacterial inhabitation do Sulfonamides cause

Answer 2

bacterialstatic

Question 3

What enzyme is affected by Sulfonamides?

Answer 3

dihydropteroate sythetase-PABA conversion

Question 4

What enzyme is affected by Trimethoprim

Answer 4

dihydrofolate reductase

Question 5

Side effects of sulfonamides

Answer 5

Sulfa-hypersensitivity & photosensitvity
hemolytic anemia
nephrotoxicity
infantile kernicterus- excessive bilirubin in blood and brain

Question 6

When is Trimethorpim used and what is better to use

Answer 6

recurrent UTIs

Fluoroquinolones better, also better with sulfonamides

Question 7

Side effects of Trrimethoprim TMP

Answer 7

pseudomembranous colitis
hematological disorders & bone marrow suppression
T(reats)M(arrow)P(oorly)

Question 8

What is the most commonly used oral folate synthesis inhibitor

Answer 8

Cotrimoxazole (TMP-SMX)

Question 9

What is TMP-SMX used for

Answer 9

Pneumocystis jiroveci pneumonia
gram+ aerobes (recurrent urinary tract infections)
H. influenzar