Pennicilins Flashcards
What do beta lactase target
Transpeptidase enzymes
What is required for B-lactams to work
proliferating cells, evade bacterial defenses, and get access to inner cell membrane
What is b-lactam has highest activity against G+ organisms?
Pen G
What extends the spectrum of b-lactams and what are examples
Adding amino groups-Ampicillin, amoxicillin
Paring with b-lactamase inhibitors-
What penicillin is most effective against staph (not MRSA)
nafcillin
What do monobactams work against
gram - bacteria
What penicillin is effective against pseudomonas
Ureidopenicillins
What are carboxypenicillins active against
Gram - bacteria
How does Pen V copare to pen G
Same spectrum, less effective
Why use amoxicillin over ampicillin
Causes less GI upset and can have higher blood levels that are not affected by the patients food consumption
What is a risk of amoxicillin use
drug interaction-reduces excretion of methotrexate, potentially elevating levels to toxic levels
What is the broadest spectrum antipseudomonal penicillin?
Piperacillin
Why use monobactams?
Does not cause IgE-mediated penicillin allergy
What are side effects of monobactams
pseudomans colitis
Common side effects of penicillins
Hypersensitivity reactions,
Local effects
Superinfection risk
Large dose of Pen G may produce lethargy, confusion, twitching, seizures, kidney failure, and coma
