Protein synthesis inhibitors Flashcards
protein synthesis inhibitors
macrolides ketolides tetracyclines glycylcyclines anaerobic agents linezoid streptogramins aminoglycosides
ECSTaTic about bacteriostatic
Erythromycin Clindamycin Sulfamethoxazole Trimethoprim Tetracyclines Chloramphenicol
inhibitors of 30s
aminoglycosides
tetracyclines
inhibitors of 50s
Clindamycin, Chloramphenicol Erythromycin Lincomycin Linezolid Streptogramins
Mnemonic of protein synthesis inhibitors
Buy at 30, CCELL for 50 dollarS
protein synthesis binds to bacterial ribosomes and prevent protein synthesis
MOA of protein synthesis inhibitors
inhibit protein synthesis by binding to domain II and V on the 50s ribosomal unit blocking the ability to synthesize polypeptides
-bacteriostatic
MOA of macrolides
what are some uses of macrolides
otitis media, pharyngitis, URI/LRI
CAP, PID, exacerbations of COPD, h.plyori, MAC
3 Macrolides drugs
azithromycin
clarithromycin
erythromycin
inhibits protein synthesis by binding to domain II & V on the 23s rRNA of the 50s ribosome
MOA of Ketolide
-Telithromycin
Telithromycin
adults and oral only
major cyp450 inhibitor/ weak 2D6 inhibitor
Hepatoxicity, QT prolongation, CI in myasthenia gravis, $$$
inhibit protein synthesis by binding to the 30s ribosomal unit therefore interfering with translocation reaction
MOA of tetracyclines
uses for tetracycline
anthrax,
CAP and tick born illness use doxycline
Acne-minocycline
PCN alternative for syphilis/gonorrhea
SE of tetracycline
yellowing teeth in children <8yrs & decrease bone growth
phototoxicity, esophageal ulceration in pill gets stuck-drink with 8oz water
expired meds causes fanconi syndrome
Preg Cat D/ Lact L2
PCN alternative for syphilis & gono
SE of minocycline
coverage against CAP-MRSA take on empty stomach Soldyn for acne blue-grey stain on teeth and hard palate phototoxic Preg Cat D/ Lact L2
Coverage for tetracyclines
gram neg, I.influenza, klebsiella, e.coli, n.meningitidis,
anaerobes: actinomyces, B. fragilis, peptostreptococcus
anthrax
doxycycline ( Vibramycin, Dorynx)
MRSA coverage
Preg Cat D/ Lat L3-4
democlocycline
used for SIADH or for SCLCA
azitromycin (Z-pack)
half life 68 hrs
not a CYP3A4 interation
Clarithromycin (Biaxin) issues
needs renal adjustment
CYP3A4 inhibitor
h.pylori
SE: bad tase, GI upset, QT prolongation
erythromycin (Ery-tab, E-mycin)
CYP3A4 inhibitor
SE: diarrhea, GI upset, QT prolongation
dosage for clarithromycin
adults: 250-500 mg Q6hrs
peds7. 5-15 mg/kg/d x 2 divided doses
inhibit protein synthesis by binding to 50s ribosome
MOA of anaerobic agents
coverage for Clinda and Lincomycin
gram positive, GABHS, anaerobes
alterative for PCn allergies
inhibits the assembly of bacterial 23s ribosomal unit of 50s subunit preventing the formation of a functional 70s initiation complex that is needed for translational process of bacterial protein synthesis
-MAOI inhibitors
MOA of Oxazolidinone: Linezolid
Se of CLinda/Lincomycin
C. diff, fever, rash, hepato
coverage of linezolid
VRE, MRSA, MDRSP
