Antifungals

Question 1

binds to ergosterol in cell wall therefore increasing permeability, leakage of cellular contents=death

Answer 1

MOA of amphotericin (Fungizone)

Question 2

fungistatic
targets new skin, binds to keratin thereby preventing new fungi infection of keratinous structures
binds to microtubules in the mitotic spindle-inhibits mitosis

Answer 2

moa of griseofuivin

Question 3

uses of Griseofulvin

Answer 3

ringworm, athletes foot, onychomycosis

prey cat D/x

Question 4

inhibits ergosterol synthesis through inhibition of sequalene epoxies therefore increasing permeability, leakage of cellular contents= death

Answer 4

MOA of Terbinafine (laminal)

Question 5

Issues of terbinafine (laminal)

Answer 5

GI, malasise
hepatotoxic-baseline & periodic AST/ALT
rifampin and Cimetidine increases clearance