Protein Synthesis Inhibitors

Question 1

What’s the side effects of the Aminoglycosides?

Answer 1

• Nephrotoxicity (reversible),
• Ototoxicity (irreversible),
• neuromuscular blockade
• Avoided in pregnancy

Question 2

What’s the uses of Streptomycin?

Answer 2

Tuberculosis, plague, tularemia, and brucellosis.

Question 3

the uses of Tobramycin?

Answer 3

ophthalmic

Question 4

The uses of the Kanamycin, Amikacin?

Answer 4

to treatment of multi-drug-resistant

Question 5

The uses of the Neomycin?

Answer 5

bowel surgery orally,

Question 6

The uses of the TETRACYCLINES?

Answer 6

• Drug of choice in the treatment of most infections caused by rickettsiae and Borrelia sp, including : Rocky Mountain spotted
fever and Lyme disease.
• Tetracyclines are also excellent drugs for the treatment of Mycoplasma, chlamydiae pneumoniae,
• Plague, tularemia, and brucellosis
• Malaria
• cholera
• H pylori
• Acne

Question 7

The side effect of the TETRACYCLINES?

Answer 7

Gastrointestinal upset.
• Hepatotoxicity.
• Photosensitivity.
• Deposition in bone and teeth causing yellow discoloration.
• Fanconi syndrome

Question 8

MACROLIDES?

Answer 8

ERYTHROMYCIN

CLARITHROMYCIN

AZITHROMYCIN

Question 9

Drug of choice in diphtheria??

Answer 9

ERYTHROMYCIN

Question 10

What’s the side effects of the ERYTHROMYCIN?

Answer 10

to a direct stimulation of gut motility

Acute cholestatic hepatitis

Question 11

What’s the uses of the CLARITHROMYCIN?

Answer 11

H.pylori

Question 12

Uses of the CLINDAMYCIN?

Answer 12

• Skin and soft tissue infections
• Anaerobic infections (above diaphragm)

Question 13

C difficile colitis ( the most common drug to cause it)?

Answer 13

CLINDAMYCIN

Question 14

What’s the side effects of the CHLORAMPHENICOL?

Answer 14

• Aplastic anemia
• Gray baby syndrome