gonades hormones Flashcards
Estrogen?
Estradiol
Estrone
(conjugated estrogens)
Ethinyl-estradiol
(Semi-synthetic)
What is effect of Estrogen?
• Growth of secondary sex characteristics (male + female)
• Role in ovulation and pregnancy
• Role in bone density modulation (male + female)
• Role in mineral, carbohydrate, protein and lipid metabolism
Ueses of Estrogen?
•Primary Hypogonadism
• Postmenopausal Hormonal Therapy
• Oral Contraceptives
Selective Estrogen Receptor Modulators (SERMs)?
Tamoxifen
Clomiphene
Raloxifene
Estrogen Antagonist
(Receptor antagonist)?
Fulvestrant
Aromatase inhibitors
(Aromatase inhibitors)?
anastrozole
Spironolactone
Derivative?
Drospirenone
Side effects of Norethindrone derivatives?
hirsutism, Masculinization
What’s the ANTI-PROGESTERONES?
Mifepristone
Progesterone antagonist side effects?
vaginal bleeding, abdominal pain and cramping
Oral contraceptive
(Progestin Only) how to be given?
Oral and implants= levonorgestrel
IM injections= medroxyprogesterone
IUD
Combined pills.
• Monophasic (a fixed amount of
estrogen & progestin).
• Biphasic (2 doses) (a fixed
amount of estrogen, while
amount of progestin increases
stepwise in the second half of the
cycle).
• Triphasic (3 doses) (amount of
estrogen; fixed or variable &
amount of progestin increases
stepwise in 3 phases).
Anabolic steroids?
Oxandrolone
Nandrolone
Androgen Receptor antagonists?
Flutamide
5-a-reductase inhibitors?
Finasteride
What’s the side effects of Finasteride?
• Impotence.
• Gynecomastia.
Block the enzyme that convert testerone to
dihydrotesterone.?
Finasteride
