Protein Synthesis Inhibitors

Question 1

Broad spectrum agents that act on 30S subunit

Answer 1

tetracycline, aminoglycosides

Question 2

broad spectrum agents that acts on 50S subunit

Answer 2

ketolide/macrolide, chloramphenicol

Question 3

narrow spectrum agents that act on 50S subunit

Answer 3

linezolid, streptogramins, lincosamide

Question 4

drugs that block polypeptide exit on 50S, preventing chain elongation

Answer 4

macrolide, clindamycin (lincosamide), streptogramin

Question 5

inhibit formation of peptide bond on 50S

Answer 5

chloramphenicol

Question 6

prevent formation of 50/30S ribosomal complex

Answer 6

linezolid

Question 7

interfere with binding of tRNA to ribosomal complex

Answer 7

tetracycline

Question 8

causes mRNA misread, interferes with the initiation complex of 30S & 50S with mRNA

Answer 8

aminoglycoside

Question 9

3 essential structures for protein synthesis

Answer 9

mRNA, tRNA, rRNA

Question 10

carries codons with encoded nucleoides

Answer 10

mRNA

Question 11

carries amino acids to rRNA for the corresponding rRNA coding

Answer 11

tRNA

Question 12

composed of the 50S subunit and the 30S subunit

Answer 12

rRNA