Drugs Used In Coagulation Disorders Flashcards
refers to the finely regulated dynamic process of maintaining fluidity of the blood, repairing vascular injury, and limiting blood loss while avoiding vessel occlusion and inadequate perfusion of vital organs
Hemostasis
vessel occlusion
thrombosis
the cessation of blood loss from a damaged vessel
Hemostasis
compensatory mechanism to prevent/reduce blood loss
vascular spasm
product is fibrin
blood clot formation
blood clot formation is synonymous to
coagulation cascade
Common causes of dysregulated hemostasis
- hereditary or acquired defects in the clotting mechanism
- secondary effects of infection or cancer
intricately balanced and designed to stop bleeding at the site of vascular injury
Coagulation system
T/F: The coagulation system is intricately balanced and designed to stop bleeding at the site of vascular injury through complex interactions between the vascular endothelium, platelets, procoagulant proteins, anticoagulant proteins, and fibrinolytic proteins.
True
Three key mechanisms that facilitate hemostasis
- vascular constriction
- primary platelet plug formation (primary hemostasis)
- clot propagation through fibrin formation (secondary hemostasis)
platelets that circulate in the blood
inactivated platelets
type of platelets in the presence of injury
activated platelets
initial phase of the blood coagulation process
vascular constriction
limits the flow of blood to the area of injury
vascular constriction
absolutely required for hemostasis to proceed
Activation of platelets
Platelets become activated by _________
thrombin
Activated platelets aggregate at the site of injury, forming a _________________________________.
temporary, loose platelet plug
Platelets clump by binding to ___________ that becomes exposed following rupture of the endothelial lining of vessels.
collagen
forms and entraps the plug to ensure the stability of the initially loose platelet plug
fibrin mesh
fibrin mesh is aka
clot
released by endothelial cells in response to injury
von Willebrand factor (vWF)
act as bridge for platelets to adhere to collagen
von Willebrand factor (vWF)
T/F: Once platelet attaches to collagen through the vWF, it becomes activated
True
GP1b receptor is found in ?
the platelet
vWF would attach to this receptor to adhere platelet to collagen
GP1b receptor
vWF deficiency or lack of mesh formation would result to
bleeding
overdose of anti-platelet drug
bleeding
T/F: Major side effect of anti-platelet drug is always bleeding
True
precursor of TXA2
cyclooxygenase
action of this receptor is vasoconstriction to prevent blood loss
5-HT receptor
active fibrinolytic enzyme
Plasmin
a combination of streptokinase and the proactivator plasminogen
Anistreplase
inhibits the activation of plasminogen to plasmin and is useful in some bleeding disorders
Aminocaproic acid
What coagulation factor is used to produce fibrin clot?
Factor I (Fibrinogen)
What coagulation factor is used to produce thrombin needed for the conversion of fibrinogen to fibrin?
Factor II (Prothrombin)
Factor II (Prothrombin) target the actions of what
heparin, dabigatran, warfarin (synthesis)
