Agents used in Dyslipidemia Flashcards
problem with lipid levels in the blood
Dyslipidemia
complexes that transport plasma lipids
lipoproteins
6 types of lipoproteins
- chylomicrons
- very low-density lipoproteins
- Intermediate-density lipoproteins
- low-density lipoproteins
- high-density lipoproteins
- apolipoproteins
lipids are made up of
cholesterol and TAGs
site of cholesterol synthesis
Liver
T/F: 95% of diet contain TAGs
True
largest lipoprotein that transports TAGs and cholesterol from diet
chylomicrons
Where do chylomicrons transport TAGs and cholesterol to?
adipose tissues
content of chylomicron remnants
cholesterol
T/F: Chylomicron remnants are also called “cholesterol-rich chylomicron remnants”
True
chylomicron remnants are transported where?
liver
counterpart of chylomicron that carries TAGs and cholesterol
VLDL
carry cholesterol to the liver and is a source of LDL
IDL
removes excess cholesterol from tissue and transport it back to the liver
HDL
Disorders of lipid and lipoprotein metabolism
Dyslipidemia
Characterized by lipid abnormalities
Dyslipidemia
lipid abnormalities include …
- Elevated triglycerides
- Elevated low density lipoprotein (LDL)
- Elevated total cholesterol (TC)
- Reduced high density lipoprotein (HDL)
Etiology of dyslipidemia`
- Primary causes
- Secondary causes
dyslipidemia caused by genetics
primary cause
dyslipidemia caused by lifestyle or disease
secondary cause
secondary dyslipidemia is also called
acquired dyslipidemia
T/F: secondary or acquired dyslipidemias can accompany genetic disorders
True
acquired dyslipidemias accompanied by genetic disorders may be associated with …
- diet
- medication
- comorbid conditions
acquired dyslipidemias accompanied by genetic disorders associated with excessive alcohol use, anorexia, weight gain, excessive intake of carbohydrates or saturated fat
diet
acquired dyslipidemias accompanied by genetic disorders associated with progestins, thiazide diuretics, glucocorticoids, β-blockers, isotretinoin, protease inhibitors, cyclosporine, mirtazapine, sirolimus
medicaiton
acquired dyslipidemias accompanied by genetic disorders associated with nephrotic syndrome, renal failure, hypothyroidism, obesity, diabetes
comorbid conditions
T/F: Dyslipidemia is asymptomatic
True
