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PHA6126 Pharmacology 2 Lecture > Agents used in Dyslipidemia > Flashcards

Agents used in Dyslipidemia Flashcards

1
Q

problem with lipid levels in the blood

A

Dyslipidemia

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2
Q

complexes that transport plasma lipids

A

lipoproteins

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3
Q

6 types of lipoproteins

A
  1. chylomicrons
  2. very low-density lipoproteins
  3. Intermediate-density lipoproteins
  4. low-density lipoproteins
  5. high-density lipoproteins
  6. apolipoproteins
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4
Q

lipids are made up of

A

cholesterol and TAGs

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5
Q

site of cholesterol synthesis

A

Liver

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6
Q

T/F: 95% of diet contain TAGs

A

True

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7
Q

largest lipoprotein that transports TAGs and cholesterol from diet

A

chylomicrons

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8
Q

Where do chylomicrons transport TAGs and cholesterol to?

A

adipose tissues

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9
Q

content of chylomicron remnants

A

cholesterol

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10
Q

T/F: Chylomicron remnants are also called “cholesterol-rich chylomicron remnants”

A

True

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11
Q

chylomicron remnants are transported where?

A

liver

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12
Q

counterpart of chylomicron that carries TAGs and cholesterol

A

VLDL

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13
Q

carry cholesterol to the liver and is a source of LDL

A

IDL

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14
Q

removes excess cholesterol from tissue and transport it back to the liver

A

HDL

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15
Q

Disorders of lipid and lipoprotein metabolism

A

Dyslipidemia

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16
Q

Characterized by lipid abnormalities

A

Dyslipidemia

17
Q

lipid abnormalities include …

A
  1. Elevated triglycerides
  2. Elevated low density lipoprotein (LDL)
  3. Elevated total cholesterol (TC)
  4. Reduced high density lipoprotein (HDL)
18
Q

Etiology of dyslipidemia`

A
  1. Primary causes
  2. Secondary causes
19
Q

dyslipidemia caused by genetics

A

primary cause

20
Q

dyslipidemia caused by lifestyle or disease

A

secondary cause

21
Q

secondary dyslipidemia is also called

A

acquired dyslipidemia

22
Q

T/F: secondary or acquired dyslipidemias can accompany genetic disorders

A

True

23
Q

acquired dyslipidemias accompanied by genetic disorders may be associated with …

A
  1. diet
  2. medication
  3. comorbid conditions
24
Q

acquired dyslipidemias accompanied by genetic disorders associated with excessive alcohol use, anorexia, weight gain, excessive intake of carbohydrates or saturated fat

A

diet

25
Q

acquired dyslipidemias accompanied by genetic disorders associated with progestins, thiazide diuretics, glucocorticoids, β-blockers, isotretinoin, protease inhibitors, cyclosporine, mirtazapine, sirolimus

A

medicaiton

26
Q

acquired dyslipidemias accompanied by genetic disorders associated with nephrotic syndrome, renal failure, hypothyroidism, obesity, diabetes

A

comorbid conditions

27
Q

T/F: Dyslipidemia is asymptomatic

A

True

28
Q
A

PHA6126 Pharmacology 2 Lecture (10 decks)

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