Protein synthesis inhibitor antibiotics Flashcards
1
Q
What antibiotics inhibit protein synthesis
A
Tetracyclines
Macrolides
Aminoglycosides
2
Q
Tetracyclines
A
binds 30s
inhibit transfer RNA to messenger RNA–> prevents peptide chain
Enters via Energy dependent transport system (not in humas)
3
Q
Macrolides
A
binds to 50s - blocks peptide chain
TU- alternate to Pen G,
whooping cough
AE- prolong QT - cardiac death
4
Q
Aminoglycosides
A
mech- binds to 30 s unit
- causes to premature release or make mistakes in chain
only for gram negative aerobic
AE- serious toxicity, ototoxicity
