Penicilin

Question 1

How do Penicillin’s work?

Answer 1

Beta-lactam disrupts CELL WALL

targets penicillin binding proteins

Beta lactam ring binds IRREVERSIBLY to PBP

Reduced PBP = weak wall = breakdown

Question 2

transpeptidases

Answer 2

bacterial enzyme that catalyzes formation of cross bridges between peptidoglycan polymer strands in cell wall

INHIBIT

Question 3

auytolystins

Answer 3

enzymes that cleaves bonds in cell wall allowing growth

ACTIVATE

Question 4

Bacterial resistance for penicillins

Answer 4

1) increase barrier protecting PBP
- gram negative

2) Beta-Lactamases

3) PBPs with low affinity to penicillin

Question 5

Penicillin G uses

Answer 5

gram +
NOT MRSA

Question 6

Pen. G PH

Answer 6

IM, IV

Metabolism: minimal
Excretion Unchanged in kidney

Question 7

Pen G. AE

Answer 7

least toxic, safest

Question 8

Pen V. TU

Answer 8

staphylococci infections
NOT MRSA

Question 9

Pen. V PH

Answer 9

PO- acid stability

Question 10

Ampicillin/ Amoxicillin

Answer 10

Broad spectrum

Certain gram - (E.coli, salmonella)

PO- acid stable