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hlsc final > Metabolic pathway antibiotics > Flashcards

Metabolic pathway antibiotics Flashcards

1
Q

drugs that interfere with metabolic pathway

A

Sulfonamides
Trimethoprim
Trimethoprim/Sulfamethoxazole

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2
Q

sulfonamides

A

mech: similar to PABA(folic acid)
- competitive inhibitor
- bacteria must synthesize folic acid

broad spectrum
-gram + and gram -

Kernicterus in newborns (bili in brain)

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3
Q

Trimethoprim

A

mech- suppresses synthesis of tratrahydrofolic acid

Gram-

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4
Q

Trimethoprim/ Sulfamethoxazole

A

mech: act in concert to disrupt DNA, RNA and proteins

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hlsc final (12 decks)

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