Peptic Ulcer Flashcards
1
Q
How to treat PUD
A
1) Antibacterial drugs-
- clarithromycin/ tetracycline
- Bismuth
2) H2RA
- climetidine
3) PPI
- Omeprazole
4) Others-
- sucralfate,
-misoprostol
2
Q
Clarithromycin/ Tetracyclin
A
inhibits H.Pylori protein synthesis
3
Q
Bismuth
A
- ?adhere to H.Pyl. cell walland destroy
AE: black stool/tongue
4
Q
Climetide mech
A
parietal cells of H2 receptors promote secretion gastric acid
- blocks H2 receptors
–> HEALING
5
Q
Climetide AE
A
anti-androgenic effect
- gynecomastia
- impotence
6
Q
Omeprazole
A
mech: prodrug –> activated by parietal cells
IRREVERSIBLE inhibition of H/K+ ATP proton pump enzyme that generates gastric acid
- inhibition of enzyme= block of gastric acid release
7
Q
Sucralfate
A
under mild acidic conditions a stick gel is produced to band aid ulcer
8
Q
misoprostol
A
ulcers from long term NSAID use
mech: serves as replacement for prostaglandins
