Protein Structure - Globular & Fibrous Proteins Flashcards
1
Q
What are some properties of globular proteins?
A
- Round / spherical
- Soluble in water
- Have functional role
- Contain several types of secondary structure
2
Q
Name 3 globular proteins
A
- Insulin
- Myoglobin
- Haemoglobin
3
Q
What are some properties of fibrous proteins?
A
- Long and narrow
- Provide strength and support
- Insoluble in water (high concentrations of hydrophobic amino acids)
4
Q
How many chains typically make up collagen?
A
3
- 2x alpha-1 chains
- 1x alpha-2 chain
5
Q
How many families of collagen molecules are there?
A
20
6
Q
What disease is caused by the replacement of Glycine in defective collagen molecules?
A
Osteogenesis imperfecta
(Abnormal bone formation)
7
Q
What causes sickle cell anaemia?
A
- A single amino acid substitution in the beta-globing chains in haemoglobin
- Glutamic acid to valine
8
Q
What causes Phenylketonuria (PKU)?
A
- A deficiency in the enzyme phenylalanine hydroxylase (PAH)
- PAH changes Phenylalanine to Tyrosine
- Concentrations of phenylalanine build up in the body to toxic levels and cause brain damage
9
Q
What mutation causes PKU?
A
When Argenine is changed to Tryptophan
