protein structure Flashcards
tertiary structure: differentiate between the different types of bonds that combine to stabilise a particular protein conformation
1
Q
what bonding is present in the tertiary structure
A
covalent bonds (incl. disulphide bridge in cysteine); hydrogen bonds; ionic interactions/salt bridges; Van der Waals; hydrophobic interactions
2
Q
what must cysteine have to form a disulphide bond
A
a free SH group so it can be oxidised
3
Q
what is a hydrogen bond
A
d+ H engaged in bond between 2 d- atoms
4
Q
what is an ionic interaction
A
electrostatic attraction between charged side chains
5
Q
why are interior ionic interactions stronger
A
at exterior counter ions neutralise charge
6
Q
what are Van der Waals forces
A
fluctuating e- cloud induce dipole; strong net force if appropriate distance (don’t repel)
7
Q
how is a hydrophobic surface produces
A
hydrophobic interactions are packed entirely
