membrane trafficking

Question 1

pathway of vesicular transport

Answer 1

RER → Golgi → other organelles/trans-Golgi network → plasma membrane

Question 2

directions of cis and trans sections of Golgi

Answer 2

cis points to ER; trans points to membrane

Question 3

what happens in the Golgi

Answer 3

sugar chains added in RER are modified in sequence; cargo sorting and vesicle formation

Question 4

how are vesicles moved

Answer 4

moved via microtubules and actin (motor proteins)

Question 5

what proteins allows vesicle fusion with the the membrane

Answer 5

tether/dock proteins

Question 6

what are vesicles coated in

Answer 6

clathrin

Question 7

dieseases affecting folding of proteins

Answer 7

cystic fibrosis, SMED-SL

Question 8

cystic fibrosis as disease affecting protein folding

Answer 8

CFTR mutation: Cl- channel in membrane misfolded and degraded

Question 9

SMED-SL as disease affecting protein folding

Answer 9

DOR2 mutation: cell surface protein kinase receptor for collagens misfolded and degraded

Question 10

familial hypercholesterolaemia as disease affecting endocytosis

Answer 10

LDLR not produced or functional