protein funnction cytoskeleton

Question 1

actin

Answer 1

basic building blocks of microfilaments

Question 2

G actin

Answer 2

globular protein

Question 3

f actin

Answer 3

filament polymer

Question 4

myosin

Answer 4

actin binding protein

Question 5

cytoskeleton

Answer 5

supports cell and aids movement, actin, microtubules, intermediate filaments (keratin, collagen, lamin)

Question 5

Intermediate filaments

Answer 5

different kinds but evolutionarily related, strength (nails hair), cannot be used as tracks, stable, only metazoan

Question 6

alpha keratin (hair)

Answer 6

➢ Two strands of alpha-keratin, oriented
in parallel, form supertwisted left-
handed coiled coil
➢ Interacting surface made up with
hydrophobic amino acids
➢ Rich in hydrophobic amino acids:
Ala, Val, Leu, Ile, Met and Phe

Question 7

keratinocytes

Answer 7

epidermis cells

Question 8

basal keratinocytes

Answer 8

epidermal stem cells

Question 9

Collagen triple helix

Answer 9

➢Unique secondary structure, left-
handed helix
➢Three amino acids per turn
➢Three peptide chains supertwisted
right-handed
➢Triple helix repeat sequence: G-X-Y
➢X is often proline and Y is often
hydroxyproline

Question 10

Lamin

Answer 10

➢Line the inner nuclear envelope
➢Major components of nuclear lamina
➢Provide nuclear structure and organization
➢Interacting to microfilaments (actins), intermediate
filaments and microtubules
➢Providing physical linkage of the nucleus and
cytoskeleton

Question 11

lamin A mutation

Answer 11

hutchinson-Gilford Progeria Syndrome (Progeria)

Question 12

mutation in KRT5/14 keratin

Answer 12

epidermolysis bullosa simplex (EBS blistering)

Question 13

cadherins

Answer 13

transmembrane proteins

Question 14

ECM

Answer 14

extracellular matrix
➢Collagens important in ECM
➢Absence of the key ECM proteins leads to dwarfism
➢Severe phenotype in many tissues, including blistering diseases