Protein 5 Flashcards
–Positive acute phase: increased during
metabolic stress
–Negative acute phase: decreased during
metabolic stress
What is Acute phase response
inflammation that can occur with metabolic stress
What is metabolic stress
A hyper metabolic, catabolic state
When does metabolic stress occur
In response to injury/trauma, sepsis, and some diseases
Under metabolic stress what is produced by the immune cells
Cytokines
Cytokines lead to?
Increased levels of several hormones
What is a side effect of metabolic stress on blood glucose
Hyperglycemia
Because of insulin resistance
What are 4 negative acute phase proteins
- Albumin
- Prealbumin (transthyretin)
- Retinol binding protein
- Transferrin
Positive acute phase proteins
C-reactive protein (CRP)
Negative acute phase proteins are good indicators of
morbidity and mortality and recovery from acute illness
Are negative acute phase proteins a good indicator of nutrition status
No
Assessment of NAP proteins gives dietitians a means to identify the patients that are most lik e l y t o d e v e l o p
m a l n u t r i t i o n
Glutathione is important for
Maintaining antioxidant balance in cells
Free radical scavenger
What does glutathione consist of
Glutamate
Glycine
Cysteine
(Contains SH group)
Albumin half life
18-21 days
Prealbumin half life
2-3 days
Retinol binding protein half life
12 hours
Transferrin half life
8-10 days
Albumin function
Carrier of nutrients
Maitinence of blood pressure
Prealbumin function
Transport thyroxine and retinol
Transferrin function
Transports iron
Retinol binding protein
Present as complex of several proteins/molecules
Monitored blood Proteins can be divided into
positive acute phase and negative acute phase proteins
