Prostate Pharm

Question 1

• Prostate CA
• GnRH agonist. Inhibits synthesis of androgen and estrogens
• Impotenence, hot flashes, HA

Answer 1

Leuprolide (Lupron)

Question 2

• Prostate CA
• Used with Leuprolide
• Antiandrogen, competative agonist
• Hot flashes, impotence, n/v, gynecomastia
• hepatoxocity BLACK BOX

Answer 2

Flutamide

Question 3

• BPH
• 5-alpha reductase inhibitor–> decreases prostate size. Prevents conversion of testosterone to dihydrotestosteone via 5 alpha reductase

Answer 3

Finasteride

Question 4

-BPH, HTN
alpha 1 receptor blockers.
decrease tone in smooth muscle of bladder neck, increasing urine flow
-Hypotension

Answer 4

Prazosin, terazosin, tamulosin (flomax)

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