GYN Malignancies

Question 1

-HPV: HPV (16 &18) -Metrorrhagia, postcoital spotting, cervical ulceration. Cervix does not move on exam. -Hysterectomy

Answer 1

Cervical

Question 2

-Malignant form of hydatidorm mole -Continued, recurrent bleeding

Answer 2

Choriocarcinoma

Question 3

-Risk: Long term exposure to estrogen w/o progesterone compliment; obesity; DM, nuilip, PCOS w/ long anovulation -S/S Abn. bleeding, 50-70yrs -DX: PAP, US, Biopsy -Tx: Progestines, hysterectomy

Answer 3

Endometrial CA

Question 3

-Risk: HPV -Often asymptomatic, bleeding, mass/plaque/ulcer

Answer 3

Vaginal

Question 4

-Non-viable fertilized egg implants in uterus Grape-like clusters enlarged edatous villi, benign -Risk: more common in asians; prior spontaneous -N/V, uterine bleed, amenorrhea/irregularity

Answer 4

(Gestational Trophoblastic disease) Hydatidiform mole

Question 6

-Common, but often benign. Deadly when not -Risk: BRCA1>BRCA2; 1st degree relatives -Vague GI discomfort, pelvic pressure/pain, asymptomatic -Dx: US; CA 125 -Tx: Chemo; ooporectomy; hysterectomy

Answer 6

Ovarian

Question 7

Risk: BRCA 1; 60s-70yrs; 1st degree relative -Firm, ill-defined margins, fixated mass. Nipple retraction,

Answer 7

Breast cancer

Question 8

-Risks: HPV; prolonged vulvar irritation -S/S: >50yrs, lesion, growth, mass, PRURITIS -Biopsy/excision

Answer 8

Vulvar CA