Prostate Cancer Flashcards
What are the risk factors for prostate cancer? (5 things)
- Age
- FHx
- High testosterone
- Black
- Obesity
What is the cause of growth in prostate cancer?
High androgens (testosterone / dihydrotestosterone)
What is the most common type of prostate cancer?
Adenocarcinoma (95%)
Where do prostate adenocarcinomas arise from? (3 things)
- Peripheral zone (75%)
- Transitional zone (20%)
- Central zone (5%)
What are the types of prostate adenocarcinoma? (2 things)
- Acinar adenocarcinoma (most common prostate cancer)
- Ductal adenocarcinoma
Where does Acinar adenocarcinoma arise from?
Glandular cells lining prostate
Where does Ductal adenocarcinoma arise from?
Cells lining duct of prostate gland
Which prostate adenocarcinoma grows + metastasises fastest?
Ductal adenocarcinoma
What are the clinical features of prostate cancer? (9 things)
- LUTS (freq, urgency, weak stream)
- Nocturia
- Haematuria (adv)
- Dysuria (adv)
- Incontinence (adv)
- Suprapubic pain (adv)
- Weight loss (metastasis)
- Bone pain (metastasis)
@ DRE (digital rectal examination)
9. Hard + irreg prostate
What are the some differentials that present similarly to prostate cancer? (6 things)
- BPH (also causes LUTS)
- Prostatitis
(also present with haematuria)
- Bladder cancer
- Urinary stones
- UTI
- Pyelonephritis
How do you differentiate between Prostatitis and Prostate cancer? (2 things)
- Prostatitis = perineal pain
- Prostatitis = neuts @ urinalysis
What lab test should be done for PSA?
PSA (prostate specific antigen test)
What is PSA?
Serum antigen produced by malignant AND healthy cells in prostate
RAISED in prostate cancer
How can PSA be raised artificially? (5 things)
- BPH
- Prostatitis
- Vigorous exercise (biking)
- Ejaculation
- Recent DRE
What other tests can you do to increase the accuracy of a PSA test? (2 things)
- Free:total PSA ratio (low = more likely cancer)
- PSA density (high = more likely cancer)