Prolactin & Galactorrhoea Flashcards
1
Q
Describe the physiological release of prolactin?
A
Prolactin is released from the anterior pituitary gland.
Dopamine is a primary prolactin releasing inhibitor. (Gate holding the horse in the stable)
2
Q
What can cause a raised prolactin?
A
- Prolactinoma
- Pregnancy
- Oestrogens
- Physiological: stress, exercise, sleep
- Acromegaly: 1/3 of patients
- PCOS
- Primary hypothyroidism (due to thyrotrophin releasing hormone (TRH) stimulating prolactin release)
3
Q
What drugs can cause a raised prolactin?
A
- Metoclopramide, domperidone
- Phenothiazines
- Haloperidol
- Very rare: SSRIs, opioids
4
Q
What are some features of excess prolactin in men?
A
Impotence, loss of libido and galactorrhoea
5
Q
What are some features of excess prolactin in women?
A
Amenoorhoea and galactorrhoea
6
Q
What drug is used to treat galactorrhoea?
A
Bromocriptine
A dopamine agonist
