Progestins & Anti-progestins

Question 1

PROGESTINS

Answer 1

Are Synthetic Progesterones

Either:

1. ) Testosterone derivative
2. ) Progesterone derivative

Question 2

What are the uses of PROGESTINS?

Answer 2

Contraceptives
HRT (Hormonal Replacement Therapy)
Gynecological conditions ( secondary amenorrhea, endometriosis, AUB)
Endometrial Carcinoma

Question 3

ANTI-PROGESTINS (mu)

Answer 3

MIFEPRISTONE ( for ABORTION)

ULIPRISTAL (EMERGENCY CONTRACEPTIVE)– within 5 days or 120 h after unprotected sex

Question 4

Other roles of progesterone aside from role in reproductive organs?

Answer 4

Bone strength

Elasticity of skin

Question 5

Progesterone derivative PROGESTINS

Answer 5

Medroxyprogesterone
Hydroxyprogesterone
MEGESTROL Acetate

Question 6

Testosterone derivatives PROGESTINS

Answer 6

Derivatives of 19-NORTESTOSTERONE

EX:

old: DANZOL, NORGESTREL, LEVONORGESTREL, ETHYNODIOL
new: DESOGESTREL, NORGESTIMATE, ETONOGESTREL

Question 7

Progestins

Answer 7

Dec . Growth &
Inc. Vasularization of endometrium

Thickens cervical mucus

Question 8

Progestin administration

Answer 8

PO, IUD, IM, TD implant

Can be used in combination with Estrogen