Androgens & Antiandrogen Flashcards

1
Q

Endogenous ANDROGEN

A

TESTOSTERONE

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2
Q

Synthetic Androgen

A

Testosterone Derivatives

Anabolic Steroids

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3
Q

Testosterone Derivatives

A

Fluoxymesterone

Methyltestosterone

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4
Q

Anabolic Steroids

A

NANDROLONE

OXANDROLONE

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5
Q

Anbolic Steroids

A

Limited Clinical Use
Mostly for APLASTIC ANEMIA
Abused by athletes to inc. Muscle mass!

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6
Q

Anti-Androgen

A

5 alpha reductase inhibitor ( transforms Testosterone to Dihydrotestosterone [DHT-More potent form of testosterone])

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7
Q

Androgens USE?

A

Used when physiologic testosterone is below normal ( primary/ secondary hypogonadism)

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8
Q

Anti-Androgen USE?

A

Prostate CA
BPH
Hirsutism in females
Male pattern baldness in males

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9
Q

Anti-Androgens

A

Androgen Receptor Inhibitor
5 alpha-reductase inhibitor
Testosterone synthesis inhibitor

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10
Q

Androgen Receptor Inhibitor

A

FLUTAMIDE

SPIRONOLACTONE

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11
Q

FLUTAMIDE

A

Androgen receptor inhibitor
MOA: DECREASE TRANSLOCATION OF STEROID RECEPTOR TO NUCLEUS

For PROSTATE CANCER

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12
Q

Side effects of FLUTAMIDE

A
Gynecomastia
Hot flashes
Breast tenderness
Dec. Libido
Erectile dysfunction
GI disturbances
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13
Q

SPIRONOLACTONE

A

Androgen Receptor Inhibitor
Mainly used as DIURETIC
Tx for HIRSUTISM in females and PCOS
Reduce male pattern baldness

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14
Q

SPIRONOLACTONE

A

SE: Gynecomastia

Amenorrhea

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15
Q

5 alpha reductase inhibitor

A

FINASTERIDE

For BPH

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