Androgens & Antiandrogen Flashcards
Endogenous ANDROGEN
TESTOSTERONE
Synthetic Androgen
Testosterone Derivatives
Anabolic Steroids
Testosterone Derivatives
Fluoxymesterone
Methyltestosterone
Anabolic Steroids
NANDROLONE
OXANDROLONE
Anbolic Steroids
Limited Clinical Use
Mostly for APLASTIC ANEMIA
Abused by athletes to inc. Muscle mass!
Anti-Androgen
5 alpha reductase inhibitor ( transforms Testosterone to Dihydrotestosterone [DHT-More potent form of testosterone])
Androgens USE?
Used when physiologic testosterone is below normal ( primary/ secondary hypogonadism)
Anti-Androgen USE?
Prostate CA
BPH
Hirsutism in females
Male pattern baldness in males
Anti-Androgens
Androgen Receptor Inhibitor
5 alpha-reductase inhibitor
Testosterone synthesis inhibitor
Androgen Receptor Inhibitor
FLUTAMIDE
SPIRONOLACTONE
FLUTAMIDE
Androgen receptor inhibitor
MOA: DECREASE TRANSLOCATION OF STEROID RECEPTOR TO NUCLEUS
For PROSTATE CANCER
Side effects of FLUTAMIDE
Gynecomastia Hot flashes Breast tenderness Dec. Libido Erectile dysfunction GI disturbances
SPIRONOLACTONE
Androgen Receptor Inhibitor
Mainly used as DIURETIC
Tx for HIRSUTISM in females and PCOS
Reduce male pattern baldness
SPIRONOLACTONE
SE: Gynecomastia
Amenorrhea
5 alpha reductase inhibitor
FINASTERIDE
For BPH