Aromatase Inhibitors

Question 1

What is Aromatase?

Answer 1

Androgens —> Estrogen (via AROMATASE Enzyme)

Question 2

Aromatase Inhibitor

Answer 2

■ Inhibiys aromatase to produce estrogen

■ Use: ER+ Breast CA in POSTMENOPAUSALS

Question 3

AI Side effects

Answer 3

Dec Estrogen –> CVD, osteo..

• usually AI given with biphosphonates

Question 4

AI Classes

Answer 4

○Type I
• IRREVERSIBLE BINDING
•ANA & LET
• Anastrozole & Letrozole (hairloss)

○Type II
• REVERSIBLE
• EXE
• Exemestane (visual disturbances)

○ PO