Estrogens & Anti-estrogens

Question 1

Synethetic Estrogens

Use

Answer 1

Primary amenorrhea
Primary hypogonadism
Dec. Estrogen levels
Contraceptives
Hormonal Replacement Therapy (HRT) --> Relieve menopausal Sx

Question 2

Anti-estrogens

Answer 2

1. Full Antagonist

2. SERMs- Selective Estrogen Receptor MODULATORS (Agonist/antagonist to some tissues)

Question 3

Anti-Estrogen USES

Answer 3

Full antagonist & SERMs- Breast CA

SERMs- Osteoporosis

Question 4

Synthetic Estrogen Receptor Agonist

Answer 4

Mestranol
Diethylstilbestrol (DES)
    * in utero= VAGINAL ADENOSIS, VAGINAL      
        ADENOCA
Ethinyl Estradiol

• given PO, TD, Vaginal, IM

SE: Vaginal bleeding, breast tenderness
Inc. Risk for thromboembolic events in post menopausal women –> DVT
Inc. Risk ENDOMETRIAL CA (when given w/o PROGESTERONE to counteract effect on emdometrium)
Small inc. Risk of BREAST CA

Question 5

SERMs

Answer 5

TAMOXIFEN
CLOMIPHENE
RALIXIFENE

Question 6

TAMOXIFEN

Answer 6

Estrogen Antagonist- BREAST
*for breast CA
Partial Agonist- bones
*prevention of osteoporisis in post menopausals

SE: agonist to endometrium –> polyps, endometrial hyperplasia, inc. Risk Endometrial CA

Question 7

RALOXIFENE

Answer 7

like Tamoxifen but no Agonistic effect on endometrium

DOC TO PREVENT OSTEOPOROSIS IN POSTMENOPAUSALS

Question 8

CLOMIPHENE

Answer 8

Estrogen antagonist to HYPOTHALAMUS
preventing normal negative feedback
Increasing FSH LH
STIMULATES OVULATION

USED TO INDUCE OVULATION AND FOR INFERTILITY

CAN CAUSE MULTIPLE PREGNANCIES DUE TO MULTIPLE OVULATION AND VISUAL DISTURBANCES

Question 9

FULL Estrogen Receptor Antagonist- FULVESTRANT

Answer 9

:)