Progesterone-Only Injection & Implant Flashcards

1
Q

What is involved in the progesterone-only injection?

A
  • a SC or IM injection is given every 12-13 weeks
  • the injection contains medroxyprogesterone acetate
  • it is also referred to as DMPA
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2
Q

How does medroxyprogesterone acetate affect return of fertility?

A
  • it can take up to 12 months for fertility to return to normal after stopping the injection
  • this makes it less suitable for women wishing to get pregnant in the near future
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3
Q

What are the 2 commonly used versions of the injection?

A

Depo-Provera:

  • given as an intramuscular injection

Sayana Press:

  • a subcutaneous injection that can be self-administered

they both contain medroxyprogesterone acetate

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4
Q

What is noristerat and when is it used?

A
  • an alternative injection containing norethisterone
  • it works for 8 weeks
  • it is used as short-term interim contraception, such as after a partner has had a vasectomy
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5
Q

What are the UK MEC 4 criteria for using the injection?

A

active breast cancer

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6
Q

What are the UK MEC 3 criteria for using the injection?

A
  • ischaemic heart disease / stroke
  • severe liver cirrhosis / cancer
  • unexplained vaginal bleeding
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7
Q

What must be considered in older women requesting the injection?

A
  • it can cause osteoporosis
  • this is significant in older women + patients on steroids for asthma / inflammatory conditions
  • it is UK MEC 2 in women > 45 and they should switch to an alternative by age 50
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7
Q

What must be considered in older women requesting the injection?

A
  • it can cause osteoporosis
  • this is significant in older women + patients on steroids for asthma / inflammatory conditions
  • it is UK MEC 2 in women > 45 and they should switch to an alternative by age 50
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8
Q

What is the mechanism of action of the DMPA?

A

inhibition of ovulation:

  • it inhibits FSH secretion by the pituitary gland
  • this prevents the development of follicles in the ovaries

other actions:

  • thickening of cervical mucus
  • altering the endometrium to make it less accepting of implantation
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9
Q

What advice is given regarding condom use when starting the DMPA injection?

A
  • no additional protection is required if started on day 1 - 5 of the cycle
  • if started at any other time, condoms should be used for 7 days
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10
Q

What do the guidelines state about the frequency of injections?

A

women need to have injections every 12-13 weeks

  • it can be given as early as 10 weeks
  • and it can be given as late as 14 weeks where necessary (but this is not licensed)
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11
Q

What are the 2 side effects that are unique to the injection?

A

osteoporosis & weight gain

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12
Q

What are women told about their bleeding pattern prior to starting the injection?

A
  • with any progesterone-only contraception, changing to the bleeding schedule is common
  • it cannot be predicted how the woman will respond
  • bleeding may become irregular, heavier or prolonged (usually temporary)
  • most women will stop bleeding altogether** after **1 year of use
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13
Q

What are the side effects associated with the DMPA injection?

A
  • weight gain
  • acne
  • reduced libido
  • mood changes
  • headaches / flushes
  • alopecia (hair loss)
  • skin reactions at injection sites
  • OSTEOPOROSIS
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14
Q

Why can the DMPA injection cause osteoporosis?

A
  • oestrogen helps to maintain bone mineral density
  • oestrogen is mainly produced by the follicles in the ovaries
  • suppressing the development of follicles reduces the amount of oestrogen produced
  • this results in decreased bone mineral density
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15
Q

How does the DMPA injection influence cancer risk?

A

slight increase in risk of breast + cervical cancer

slight decrease in risk of ovarian + endometrial cancer

16
Q

What is the bleeding pattern typically like when starting the injection?

A
  • irregular bleeding is very common in the first 6 months
  • most women experience amenorrhoea** after using the injection for **1 year
  • if irregular bleeding persists after 6 months, alternative causes must be excluded
    • cervical screening, pregnancy test + sexual health screen
17
Q

If problematic bleeding persists whilst taking the injection, what other medication can be given?

A
  • the COCP** is taken in addition to the injection for **3 months
  • this can settle problematic bleeding
  • a short 5 day course of mefenamic acid (NSAID) is an alternative to stop bleeding
18
Q

What are the benefits associated with the injection?

A
  • improvement in dysmenorrhoea
  • improvement in endometriosis-related symptoms
  • reduces severity of sickle cell crisis in sickle cell anaemia
19
Q

What is significant about the DMPA injection and drug reactions?

A

it is NOT affected by enzyme-inducers

20
Q

Where is the progesterone-only implant positioned?

A
  • it is placed in the upper arm
  • it is beneath the skin and above the subcutaneous fat
  • it slowly releases progestogen into the systemic circulation
21
Q

How frequently does the implant need to be replaced?

A

every 3 years

22
Q

What implant is used in the UK?

What does it contain and who can have it?

A

Nexplanon

  • it contains 68mg etonogestrel
  • it is licensed for use between the ages of 18 and 40
23
Q

What are the contraindications to Nexplanon?

A

UK MEC 4:

  • active breast cancer

UK MEC 3:

  • severe liver cirrhosis / cancer
  • continuing use following cardiovascular accident
  • currently taking enzyme inducers
24
Q

What is the mechanism of action of the implant?

A
  • inhibition of ovulation
  • thickening of cervical mucus
  • altering the endometrium to make it less acceptable to implantation
25
Q

What advice is given about condom use after having the implant inserted?

A
  • no additional protection is required if the implant is inserted on day 1-5 of the cycle
  • if insertion is at any other time, condoms should be used for 7 days
26
Q

How is the implant inserted and its position checked?

A
  • lidocaine is used as a local anaesthetic
  • a special device is used to insert the implant horizontally, beneath the skin and above the subcutaneous fat
  • it is inserted ⅓ of the way up the upper arm, on the medial side
  • it should be palpable immediately
  • pressing on one end of the implant should make the other end pop up against the skin
27
Q

How is the Nexplanon implant removed?

A
  • lidocaine is used
  • a small incision is made in the skin at one end of the implant
  • the device is removed using pressure on the other end or forceps
28
Q

When is contraception required after removal of the implant?

A

contraception is required IMMEDIATELY after removal

29
Q

In which patients may the Nexplanon implant be the contraceptive of choice?

A

Unlike the COCP…

  • it can be used in obese patients
  • it does not affect the VTE risk

Unlike the depo injection…

  • it has no effect on bone mineral density
  • it does not cause weight gain
30
Q

What are the benefits to the Nexplanon implant?

A
  • it can improve dysmenorrhoea
  • it can make periods lighter / stop altogether
  • there is no need to remember to take pills
31
Q

What are the drawbacks to the use of the Nexplanon implant?

A
  • it requires a minor operation to be removed
  • worsening of acne
  • no protection against STIs
  • can cause problematic bleeding
  • implants can become bent / fractured
  • implants can become impalpable / deeply implanted
    • this requires further investigations / management
32
Q

What advice is given to women about palpating their implant?

A
  • women should palpate the implant occasionally
  • if the implant becomes impalpable, extra contraception is required until it is located
  • USS or XR can be used to locate the implant as it contains barium sulphate
  • referral to a specialist removal centre may be required
33
Q

If the implant cannot be detected after USS, what should be done?

A

CXR

  • rarely, the implant can enter blood vessels and migrate through the body
  • there is a risk of an implant entering a pulmonary artery
34
Q

What is the bleeding pattern typically like when using the implant?

A
  • ⅓ have infrequent bleeding
  • ¼ have frequent / prolonged bleeding
  • 1/5 have no bleeding
  • the remainder have normal regular bleeds
35
Q

If bleeding is problematic when using the implant, what can be done?

A
  • COCP** is given for **3 months in addition to the implant
  • this helps to settle the bleeding
  • only suitable if there are no contraindications