Professor Morris’ Lectures Flashcards
1
Q
ADME?
A
Absorption
Distribution
Metabolism
Excretion
2
Q
Bioavailability
A
% of administered drug which reaches system circulation intact
3
Q
Drugs get absorbed from stomach and small intestines and passed into the hepatic portal system and goes to the liver
A
Some drugs are metabolised extensively through their ‘first pass’ through the liver
4
Q
Absolute bioavailability (f) is calculated by comparing the amount absorbed by one route to the intravenous route
A
5
Q
How is F determined?
A
AUC - Area under curves of the route used vs intravenous route is compared and a percentage is calculated
6
Q
Bolus means singular intravenous dose
A
