Professional Phagocytes of the Innate Immune System Flashcards
1
Q
List the professional phagocytes in order of arrival to site of infection (non-resident)
A
- Neutrophils
- Macrophages
- Dendritic cells
2
Q
List the professional phagocytes in order of increasing presence in the blood
A
- Dendritic cells (millions)
- Macrophages (hundreds of millions)
- Neutrophils (billions)
3
Q
List the professional phagocytes in increasing order of lifespan
A
- Neutrophils (5 days)
- Macrophages (2 months)
- Dendritic cells (Several months)
4
Q
Neutrophils - Summarize their functions
A
- Main phagocytes
- Release oxidative bursts **(superoxides and H202) **to degrade bacteria
- **Secrete lytic enzymes **(protease and phospholipase)
- Mostly present in blood
5
Q
Macrophages - Summarize their functions
A
- Phagocytes
- **Release oxidative bursts **(superoxides and H2O2) to degrade bacteria
- Secrete lytic enzymes (protease and phospholipase)
- Mostly present in the tissues
- Also clear apoptotic cells
6
Q
What cytokines do NK cells secrete during inflammation?
A
IFN-gamma
These activate naive T cells to activate adaptive immunity.
7
Q
What cytokines do dendritic cells secrete during inflammation?
A
IFN-gamma
TNF-alpha
TGF-beta
IL-6
These activate naive T cells to activate adaptive immunity.
8
Q
What cytokines do macrophages secrete during inflammation?
A
IFN-alpha, beta, or gamma
TNF-alpha
IL-1
IL-8
These activate naive T cells to activate adaptive immunity.
