Cytokines of Innate Immunity Flashcards
1
Q
Pro-inflammatory cytokines
A
IL-1
TNF-α
IL-6
2
Q
IL-1 sources
A
Macrophages
Endothelium
Epithelium
3
Q
IL-1 targets and effects
A
- Endothelium → coagulation, inflammation, & ⇡permeability
- Liver/hepatocytes → production of acute phase proteins
- Hypothalamus → fever
- Bone marrow → ⇡production of leukocytes
4
Q
TNF-α sources
A
Macrophages
T cells
NK cells
5
Q
TNF-α targets and effects
A
- Endothelium → coagulation, inflammation & ⇡permeability
- Liver/hepatocytes → production of acute phase proteins
- Hypothalamus → fever
- Neutrophils → neutrophil activation
- Bone marrow → ⇡leukocyte production
6
Q
IL-6 sources
A
Macrophages
Endothelium
Th2 cells
7
Q
IL-6 targets & effects
A
- Liver/hepatocytes → production of acute phase proteins
- B cells → B cell proliferation
