PAMPs that drive the Innate Immune Response Flashcards
1
Q
How does the host respond to O-Ag of LPS?
A
- O-Ag triggers the alternative pathway of complement
- Gram-negative bacteria should be sensitive to MAC
- C3a and C5a stimulate inflammation and attract neutrophils to gut lumen
2
Q
How does the host respond to Lipid A of LPS?
A
Lipid A is recognized by TLR4
3
Q
How does the host respond to peptidoglycan?
A
- TLR2 responds to peptidoglycan in all extracellular bacteria
- TLR2 also responds to teichois and lipitechoic acids of gram negative bacteria
4
Q
How does the fost respond to flagella?
A
- Flagella are recognized by TLR5
5
Q
A