PAMPs that drive the Innate Immune Response Flashcards

1
Q

How does the host respond to O-Ag of LPS?

A
  • O-Ag triggers the alternative pathway of complement
  • Gram-negative bacteria should be sensitive to MAC
  • C3a and C5a stimulate inflammation and attract neutrophils to gut lumen
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2
Q

How does the host respond to Lipid A of LPS?

A

Lipid A is recognized by TLR4

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3
Q

How does the host respond to peptidoglycan?

A
  • TLR2 responds to peptidoglycan in all extracellular bacteria
  • TLR2 also responds to teichois and lipitechoic acids of gram negative bacteria
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4
Q

How does the fost respond to flagella?

A
  • Flagella are recognized by TLR5
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5
Q
A
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