Procoagulant Therapies

Question 1

These coagulation factors are made in the liver, so if you’re an alcoholic, you’ll have low levels of these factors due to liver cirrhosis, and you’ll have a difficult time coagulating.

Answer 1

2, 7, 9, and 10.

Question 2

Vitamin K is needed to make these coagulation factors.

Answer 2

2, 7, 9, and 10.

Question 3

Factor Xa job.

Answer 3

Converts Prothrombin to Thrombin

Question 4

Role of Thrombin

Answer 4

Converts Fibrinogen to fibrin (forms fibrin clot)

Question 5

Role of Plasmin

Answer 5

Fibrinolytic- breaks down the fibrin clot.

Question 6

Topical hemostatic agents

Answer 6

Gelatin Gelfoam
Hemostatic collagen
Oxidized cellulose
Topical thrombin
Fibrin sealants

Question 7

A gelatin that can be placed topically to cause hemostasis.

Answer 7

Gelfoam

Question 8

Biologically active topical hemostatic agents.

Answer 8

Topical Thrombin and Fibrin sealants.

Question 9

Physical topical hemostatic agents.

Answer 9

Hemostatic Collagen
Gelatin Gelfoam
Oxidized cellulose

Question 10

One of the most potent activators of clot formation; Gets exposed to activate the clotting cascade.

Answer 10

Collagen

Question 11

This hemostatic agent makes a mechanical matrix that causes clotting.

Answer 11

Gelfoam

Question 12

A scaffold that gets platelets to stick and form a clot.

Answer 12

Collagen

Question 13

The most thrombogenic component of the extracellular matrix.

Answer 13

Collagen

Question 14

This hemostatic agent is held in place for 2-5 mins to cause hemostasis, and is resorbable in 2-8 weeks.

Answer 14

Collagen

Question 15

Expands 3-4 times into a gelatinous mass and is bactericidal bc of its low pH.
Adsorbs blood that aids in clotting (Saturates with blood at the bleeding site to form a gelatinous mass).

Answer 15

Cellulose (Surgicel)

Question 16

This hemostatic agent is bactericidal due to its low pH.

Answer 16

Cellulose.

Question 17

Stabilizes the blood clot by converting fibrinogen to fibrin, reinforcing the fibrin mesh for platelet plugs.

Answer 17

Topical Thrombin

Question 18

Caution to take with Thrombin when using it as a hemostatic agent.

Answer 18

MUST only use it TOPICALLY bc if it gets into the circulation, it can cause thrombosis.

Question 19

Dual syringe two-component system of Fibrinogen and Thrombin

Answer 19

Fibrin sealants

Question 20

Promote clot formation

Answer 20

1) Desmopressin
2) Factor 7a
3) Platelet Rich Plasma

Question 21

Desmopressin MOA

Answer 21

Causes the release of Factor 8 and vWF to form a clot.

Question 22

Converts Factor X to Xa.

Answer 22

Factor 7

Question 23

Another name for Factor 2.

Answer 23

Prothrombin

Question 24

Composition of a PRP clot.

Answer 24

94% PLATELETS
5% RBC’s
1% WBC’s

Question 25

Two Anti-Fibrinolytics

Answer 25

Aminocaproic Acid | Tranexamic Acid

Question 26

What do anti-fibrinolytic agents degrade/inhibit?

Answer 26

Plasmin

Question 27

Aminocaproic and Tranexamic Acids are analogs of this amino acid.

Answer 27

Lysine

Question 28

This amino acid is found in blood clots and is bound by Plasminogen when it's time to degrade the clot.

Answer 28

Lysine

Question 29

This anti-fibrinolytic agent prevents the activation of plasminogen.

Answer 29

Aminocaproic Acid

Question 30

These should be used when platelet transfusion doesn't work.

Answer 30

Desmopressin and anti-fibrinolytic agents.