Procoagulant Therapies Flashcards

1
Q

These coagulation factors are made in the liver, so if you’re an alcoholic, you’ll have low levels of these factors due to liver cirrhosis, and you’ll have a difficult time coagulating.

A

2, 7, 9, and 10.

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2
Q

Vitamin K is needed to make these coagulation factors.

A

2, 7, 9, and 10.

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3
Q

Factor Xa job.

A

Converts Prothrombin to Thrombin

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4
Q

Role of Thrombin

A

Converts Fibrinogen to fibrin (forms fibrin clot)

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5
Q

Role of Plasmin

A

Fibrinolytic- breaks down the fibrin clot.

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6
Q

Topical hemostatic agents

A
Gelatin Gelfoam
Hemostatic collagen
Oxidized cellulose
Topical thrombin
Fibrin sealants
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7
Q

A gelatin that can be placed topically to cause hemostasis.

A

Gelfoam

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8
Q

Biologically active topical hemostatic agents.

A

Topical Thrombin and Fibrin sealants.

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9
Q

Physical topical hemostatic agents.

A

Hemostatic Collagen
Gelatin Gelfoam
Oxidized cellulose

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10
Q

One of the most potent activators of clot formation; Gets exposed to activate the clotting cascade.

A

Collagen

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11
Q

This hemostatic agent makes a mechanical matrix that causes clotting.

A

Gelfoam

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12
Q

A scaffold that gets platelets to stick and form a clot.

A

Collagen

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13
Q

The most thrombogenic component of the extracellular matrix.

A

Collagen

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14
Q

This hemostatic agent is held in place for 2-5 mins to cause hemostasis, and is resorbable in 2-8 weeks.

A

Collagen

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15
Q

Expands 3-4 times into a gelatinous mass and is bactericidal bc of its low pH.
Adsorbs blood that aids in clotting (Saturates with blood at the bleeding site to form a gelatinous mass).

A

Cellulose (Surgicel)

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16
Q

This hemostatic agent is bactericidal due to its low pH.

A

Cellulose.

17
Q

Stabilizes the blood clot by converting fibrinogen to fibrin, reinforcing the fibrin mesh for platelet plugs.

A

Topical Thrombin

18
Q

Caution to take with Thrombin when using it as a hemostatic agent.

A

MUST only use it TOPICALLY bc if it gets into the circulation, it can cause thrombosis.

19
Q

Dual syringe two-component system of Fibrinogen and Thrombin

A

Fibrin sealants

20
Q

Promote clot formation

A

1) Desmopressin
2) Factor 7a
3) Platelet Rich Plasma

21
Q

Desmopressin MOA

A

Causes the release of Factor 8 and vWF to form a clot.

22
Q

Converts Factor X to Xa.

A

Factor 7

23
Q

Another name for Factor 2.

A

Prothrombin

24
Q

Composition of a PRP clot.

A

94% PLATELETS
5% RBC’s
1% WBC’s

25
Q

Two Anti-Fibrinolytics

A

Aminocaproic Acid

Tranexamic Acid

26
Q

What do anti-fibrinolytic agents degrade/inhibit?

A

Plasmin

27
Q

Aminocaproic and Tranexamic Acids are analogs of this amino acid.

A

Lysine

28
Q

This amino acid is found in blood clots and is bound by Plasminogen when it’s time to degrade the clot.

A

Lysine

29
Q

This anti-fibrinolytic agent prevents the activation of plasminogen.

A

Aminocaproic Acid

30
Q

These should be used when platelet transfusion doesn’t work.

A

Desmopressin and anti-fibrinolytic agents.