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HDM > Pro-Inflammatory Cytokines > Flashcards

Pro-Inflammatory Cytokines Flashcards

1
Q

What are the pro-inflammatory cytokines

A

TNF-a, IFN-y, IL1, IL6, IL8, IL11, IL12, IL15, IL18

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2
Q

What cells secrete TNF-a?

A

M#, NK, Tcell

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3
Q

What cells secrete IFN-y?

A

NK, T cells

**The only cytokine NOT produced by M#’s****

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4
Q

What cells secrete IL-1

A

MEHKDCFB

M#, Endothelial Cells, Hepatocytes, Keratinocytes, DCs, Fibroblasts

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5
Q

What cells secrete IL-6

A

6 LBs of MEaT

M#, Endothelial cells, T cells

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6
Q

What cells secrete IL-8

A

MET 8 FB Players with New Active Chemo

M#, Endothelial cells, T cells, Fibroblasts, Platelets

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7
Q

What cells secrete IL-11

A

I haven’t found anywhere that answers that

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8
Q

What cells secrete IL-12

A

12 TaNKs in THe1 Different Deacon’sCuorum

M#, DCs

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9
Q

What cells secrete IL-15

A

Max the 15yo TaNK Pro Remembers the 8 yo’s T cell Chemo

M#

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10
Q

What cells secrete IL-18

A

Max will TaNK if he Syns at age 18

M#

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11
Q

What does TNF-a secretion lead to?

A 
HELNCO
Hypothalamus = Fever
Endothelium = inflammation and coagulation
Liver = increased acute phase proteins
Neutrophils = activation
Cachexia = Muscle & Fat
Other = apoptosis
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12
Q

What does IFN-y secretion lead to?

A

10X increase in M#; increased Abs.

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13
Q

What does IL1 secretion lead to?

A 
MEHKDCFB = HEL1
Hypothalamus = Fever
Endothelium = inflammation and coagulation
Liver = Increased APPs
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14
Q

What does IL6 secretion lead to?

A

6 LBs of MEaT
Liver = increased APPs
B cell = increased Ab-producing cells

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15
Q

What does IL8 secretion lead to?

A

MET 8 FB Players with New Active Chemo
Activation and Chemotaxis of Neutrophils

or Clean up on IL-8 = IL8 recruitment of neuts. to clear infx.

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16
Q

What does IL12 secretion lead to?

A

12 TaNKs IN THe 1 Different Deacon’sCuorum

  • *Increased IFN-y; TH1 differentiation
  • *Synergizes with IL18 –> Increased IFN-y
17
Q

What does IL15 secretion lead to?

A

Max the 15 yo TaNK Pro Remembers his 8 yo T cell Chemo

  • *T cell and NK proliferation
  • *CD8 memory cells
    • Chemotactic for T cells
18
Q

What does IL18 secretion lead to?

A

Max will TaNK IF Syn when 18

T cell and NK cell lead to IFN-y synthesis

HDM (12 decks)

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