Immunogenetics

Question 1

In MHC I molecules differences among individuals occur in which 2 domains?

Answer 1

Alpha 1 & alpha 2

Question 2

What is special about alpha 3 region on MHC I molecules?

Answer 2

invariant

Question 3

alpha 3 invariant binds to which cluster of differentiation marker?

Answer 3

CD8+

Question 4

What does B2m do?

Answer 4

Helps maintain conformation

Question 5

Most variability occurs in which region?

Answer 5

a1/a2

Question 6

MHC I binding binds how many amino acids?

Answer 6

8-10

Question 7

Which MHC I genes are the most polymorphic?

Answer 7

HLA-A,B,&C

Question 8

Which chromosome is the HLA on?

Answer 8

Chromosome 6p21.3

two-one point three, not twenty one

Question 9

What is a haplotype?

Answer 9

a set of genes that determine different antigens, but are closely linked an inherited together.

Question 10

What is another definition of haplotype

Answer 10

Observed patterns of various combinations of alleles for genes

Question 11

In MHC II molecules where is the variable region?

Answer 11

alpha 1 and beta 1 domains

The part that looks like the stingray

Question 12

Why should I care about the variable region?

Answer 12

That is where differences can occur in individuals

Question 13

CD4+ binds where in an MHC II molecule?

Answer 13

Beta-2 domain

Question 14

How many amino acids does MHC II bind?

Answer 14

13-25

Question 15

MHC II molecules can bind any only certain peptides? T or F

Answer 15

True

Question 16

Most Important Class II MHC genes

Answer 16

HLA- DP, DQ, DR