Oral Tolerance, Microflora, and Gut Immunity

Question 1

2 ways an Ag can leave lumen and enter lamina propria

Answer 1

Through M cells

Through Epithelial cells

Question 2

Enterocytes role in Ag recognition by CD4+ cells

Answer 2

Can act as local APCs expressing MHC II

Question 3

Where does T cell activation occur?

Answer 3

MLN (Mesenteric Lymph Node)

Question 4

Ag can gain direct access to the bloodstream via the gut, T or F?

Answer 4

True

Question 5

2 Major types of Anti-inflammatory mechanisms in GI

Answer 5

Immune Exclusion

Oral Tolerance

Question 6

What is immune exclusion

Answer 6

limiting pathogen colonization via secretory Abs- sIgA and sIgM

Question 7

What is oral tolerance?

Answer 7

Treg cells supress Th2, Th1, and Th17 responses to food proteins

Question 8

CD4+ CD25+ FOXP3+T_reg cells

Location

Role

Answer 8

Location - in the intestine, prevent immune response against microflora Ags

Question 9

Depeletion of T_reg cells will lead to an increase of CD4+ TH cells and ultimately to

Answer 9

Intestinal inflammation