Adaptive Immunity Cytokines

Question 1

Are the adaptive immunity cytokines secreted by B-cells or T-cells?

Answer 1

T-cells

Question 2

What cytokines are used in adaptive immunity?

Answer 2

IL2, IL4, IL5, IFN-y, IL17, TGF-b

Question 3

What secretes IL2?

Answer 3

CD4+ and CD8+ T cells

Question 4

What does IL2 secretion result in ?

Answer 4

Survival, Proliferation and differentiation of effector and regulatory T cells (= the major growth factor for T cells)

Question 5

What secretes IL-4 and IL-5?

Answer 5

CD4+ T cells and Mast cells

Question 6

What is the function of IL4?

Answer 6

B cell switching to IgE

Question 7

What is the function of IL5?

Answer 7

Activation of Eosinophils to defend against helminths

Question 8

What produces IFN-y?

Answer 8

NKs and CD4+/CD8+ T cells

Question 9

What is the function of IFN-y?

Answer 9

Activation of M#s

Question 10

What cells secrete IL17?

Answer 10

CD4+ and others

Question 11

What is the function of IL17?

Answer 11

Stimulation of Acute inflammation

Question 12

What cells secrete TGF-b?

Answer 12

CD4+ and Many others

Question 13

What is the function of TGF-b?

Answer 13

Inhibits T cell activation; differentiation of Treg cells