Principles of the vascular system Flashcards

1
Q

What is the function of arteries and arterioles?

A

Arteries and arterioles are responsible for delivering oxygen-rich blood and nutrients from the heart to organs and tissues throughout the body.

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2
Q

What is the function of venules and veins?

A

Venules and veins are responsible for carrying deoxygenated blood back to the heart, completing the circulation loop. They also serve as reservoirs for blood volume.

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3
Q

What is the function of capillaries?

A

Capillaries are tiny, thin-walled vessels that facilitate the exchange of gases (oxygen and carbon dioxide) and the transfer of nutrients between the blood and the surrounding tissues. They link arterioles to venules.

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4
Q

Can you name an example of an artery that is an anatomical end artery?

A

The central retinal artery is an example of an anatomical end artery. It does not have anastomosis (connection) with other arteries.

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5
Q

What is the unique characteristic of coronary arteries?

A

Coronary arteries are considered functional end arteries, meaning they have limited anastomosis. However, the anastomosis between coronary arteries is often insufficient.

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6
Q

What is an anastomosis?

A

An anastomosis is a connection between two blood vessels, allowing for alternative routes of blood flow.

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7
Q

What is the function of anastomoses?

A

Anastomoses ensure continued tissue perfusion when one artery is compromised or blocked, providing an alternative pathway for blood flow.

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8
Q

Can you provide an example of an anastomosis?

A

The Circle of Willis is an example of an anastomosis located at the base of the brain. It connects the major arteries supplying the brain, allowing for collateral circulation if one of the arteries becomes occluded.

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9
Q

What is the function of the ascending aorta?

A

The ascending aorta carries oxygenated blood from the left ventricle of the heart. It gives rise to the coronary arteries, which supply blood to the heart muscle.

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10
Q

What is the function of the arch of the aorta?

A

The arch of the aorta is located above the level of the T4/T5 disc. It branches to supply blood to the head, neck, and upper limbs.

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11
Q

What is the function of the descending aorta?

A

The descending aorta extends from the top of the arch to the level of the T4/T5 disc. It continues as the thoracic aorta, supplying the posterior thoracic body wall, lungs, and diaphragm.

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12
Q

What is the function of the descending thoracic aorta?

A

The descending thoracic aorta extends from the T4/T5 level to the T12 level. Its branches supply the posterior thoracic body wall, lungs, and diaphragm.

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13
Q

Where is the abdominal aorta located and what does it supply?

A

The abdominal aorta extends from the level of T12 to L4 and supplies blood to the abdominal contents, gonads, abdominal body wall, diaphragm, and other structures in the abdominal region.

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14
Q

What are the branches of the abdominal aorta?

A

The branches of the abdominal aorta include the common iliac arteries, which bifurcate into the external iliac artery and internal iliac artery. The external iliac artery continues under the inguinal ligament, while the internal iliac artery supplies the pelvis and perineum.

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15
Q

How does blood flow to the upper limb?

A

Blood flow to the upper limb starts with the subclavian artery, which becomes the axillary artery. The axillary artery further branches into the brachial artery, which then gives rise to the radial and ulnar arteries, supplying the forearm and hand.

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16
Q

How does blood flow to the lower limb?

A

Blood flow to the lower limb starts with the external iliac artery, which becomes the femoral artery. The femoral artery then continues as the popliteal artery, which further branches into the anterior tibial artery, posterior tibial artery, and the fibular artery.

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17
Q

What is the role of veins in the venous system?

A

Veins transport blood towards the heart and act as a reservoir for blood. They have thinner walls compared to arteries and lack significant amounts of elastin and smooth muscle. Veins often have a larger lumen and may contain valves that ensure unidirectional flow of blood.

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18
Q

What are venous valves?

A

Venous valves are inward projections of the intima (inner layer) of the vein, strengthened by collagen and elastic fibers. They are semi-lunar cusps attached to the venous wall. Their function is to ensure one-way blood flow towards the heart and prevent backflow.

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19
Q

Where are venous valves absent?

A

Venous valves are absent in the inferior vena cava and in the veins of the head and neck.

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20
Q

What can happen if veins dilate and increase in pressure?

A

If veins dilate due to increased pressure, the valves may not close properly, resulting in the condition known as varicose veins. Varicose veins are enlarged, twisted veins that usually occur in the legs and can cause discomfort and cosmetic concerns.

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21
Q

What are the main vessels that return deoxygenated blood to the heart?

A

The superior vena cava and inferior vena cava are the main vessels that return deoxygenated blood to the heart. Both of these vessels empty into the right atrium.

22
Q

What does the superior vena cava receive blood from?

A

The superior vena cava receives deoxygenated blood from the upper limb, head and neck, and thorax.

23
Q

What does the inferior vena cava receive blood from?

A

The inferior vena cava receives blood from the liver, lower limbs, kidneys, adrenals, gonads, and diaphragm. It does not directly receive intestinal blood.

24
Q

What is the function of the portal vein?

A

The portal vein drains intestinal blood into the liver for processing nutrients.

25
Q

What are some major veins in the thoracic cavity?

A

The major veins in the thoracic cavity include the azygos vein, hemiazygos vein, and accessory hemiazygos vein.

26
Q

What is the function of the portal vein?

A

The portal vein feeds intestinal blood into the liver for processing nutrients.

27
Q

What happens if there is a blockage in the portal system?

A

A blockage in the portal system causes blood to find an alternative route into the systemic circulation through porto-systemic anastomoses.

28
Q

How is the venous system organized in the upper and lower limbs?

A

The venous system in the upper and lower limbs has a similar organization with deep veins, superficial veins, and venae comitantes.

29
Q

What is the purpose of valves in veins?

A

Valves in veins prevent the backflow of blood and ensure that blood flows in one direction toward the heart.

30
Q

How does the leg venous pump system work

A

The leg venous pump system helps in the return of blood against gravity. It involves valves in veins and the muscular pump that compresses veins within a closed compartment.

31
Q

What are the three layers of blood vessels?

A

The three layers of blood vessels are the tunica externa (adventitia), tunica media, and tunica intima.

32
Q

What is the function of the tunica externa (adventitia)?

A

The tunica externa (adventitia) mainly consists of connective tissue fibers that protect the blood vessels and attach them to surrounding tissues.

33
Q

What is the vasa vasorum?

A

The vasa vasorum are small blood vessels that supply blood and nutrients to the tunica externa and tunica media of larger blood vessels.

34
Q

What is the main component of the tunica media?

A

The tunica media is mainly composed of smooth muscle fibers and elastin in medium and large arteries. It controls the shape and size of the vessel.

35
Q

What is the role of the sympathetic nervous system in the tunica media?

A

The sympathetic nervous system regulates the tunica media. Stimulation causes vasoconstriction, while inhibition causes vasodilation.

36
Q

What is the tunica intima?

A

The tunica intima is the innermost layer of blood vessels and consists of the endothelial lining. It reduces friction for blood flow and is easily damaged.

37
Q

What is the function of the myointimal cells?

A

The myointimal cells, located under the internal elastic lamina (IEL) in the tunica intima, play an important role in atherosclerosis when the intima thickens.

38
Q

What is atherosclerosis?

A

Atherosclerosis is the narrowing of arteries due to the buildup of plaque, consisting of fatty deposits, cholesterol, and other substances on the arterial walls. It can lead to various cardiovascular conditions, such as myocardial infarction (heart attack).

39
Q

What is thrombosis?

A

Thrombosis refers to the formation of a blood clot (thrombus) within a blood vessel. It can occur due to the rupture of an atherosclerotic plaque or in conditions like deep venous thrombosis. Thrombosis can impede blood flow and potentially lead to tissue damage or organ dysfunction.

40
Q

What is an embolism?

A

An embolism occurs when a blood clot or other foreign material (embolus) breaks away from its site of origin and travels through the bloodstream to a different location, causing a blockage. Examples include pulmonary embolism (blockage of an artery in the lungs) and cerebrovascular occlusion (blockage of a blood vessel in the brain).

41
Q

What are large elastic arteries?

A

Large elastic arteries, also known as conducting arteries, are major arteries in the body that have a diameter greater than 10mm. They are characterized by having a significant amount of elastin in their walls, particularly in the internal and external elastic laminae.

42
Q

What is the function of large elastic arteries?

A

Large elastic arteries have the ability to expand and recoil during the cardiac cycle, allowing them to accommodate the surge of blood ejected from the heart during systole and maintain continuous blood flow during diastole. Their elastic properties help in maintaining constant blood pressure and minimizing fluctuations.

43
Q

What are some examples of large elastic arteries?

A

Some examples of large elastic arteries include the aorta (entire length), brachiocephalic trunk, left common carotid artery, left subclavian artery, and pulmonary trunk. These arteries play a crucial role in distributing oxygenated blood from the heart to various parts of the body.

44
Q

What are medium muscular arteries?

A

Medium muscular arteries are arteries with a diameter ranging from 0.1mm to 10mm. They are characterized by having a large amount of smooth muscle in their walls, allowing them to regulate the diameter of the blood vessel and control the flow of blood. These arteries play a crucial role in maintaining constant blood flow during diastole and are commonly found among named arteries.

45
Q

What are small arteries and arterioles?

A

Small arteries and arterioles are arteries with a diameter of 0.3mm or less. They are responsible for controlling the filling of capillaries and contribute to arterial pressure regulation. These vessels have a smaller diameter compared to medium and large arteries and play a crucial role in regulating blood flow to specific tissues and organs.

46
Q

What are the characteristics of veins?

A

Veins have a thicker tunica externa compared to their tunica media, and their walls are less muscular compared to arteries. Examples of large veins include the superior vena cava, inferior vena cava, and portal vein. Medium and small veins include superficial limb veins and venules. The smallest veins, known as postcapillary venules, have a diameter ranging from 8-100μm and possess a very thin tunica externa and tunica media. Veins lack elastin and elastic laminae.

47
Q

What is the structure of capillaries?

A

capillaries consist of a single layer of flattened endothelial cells, known as the tunica intima.
They lack a tunica media and tunica externa.
Capillaries allow for the exchange of substances between the blood and extracellular fluid (ECF).
They provide nutrients to tissues and remove waste products.

48
Q

What are continuous capillaries?

A

Continuous capillaries have an uninterrupted endothelium.
They are the most common type of capillary.
Examples include capillaries found in muscle and the nervous system.

49
Q

What are fenestrated capillaries?

A

Fenestrated capillaries have pores in their endothelium.
They are found in organs such as endocrine glands, intestines, pancreas, and kidneys.

50
Q

What are sinusoids?

A

Sinusoids are highly specialized vascular channels.
They have a larger diameter compared to capillaries.
Sinusoids are lined with endothelial cells and have a scanty or absent basement membrane.
The endothelial cells are highly fenestrated, with large pores and gaps between them.
Sinusoids are found in organs such as the liver and spleen.