Principles of Hemostasis Flashcards

1
Q

What are the proteins that inhibit the clotting cascade?

A

TFPI
ATIII
Protein C, Protein S

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2
Q

What are the proteins that promote clot lysis?

A

t-PA

Plasmin

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3
Q

Alpha granules consist of

A

Fibrinogen, vWF

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4
Q

Delta granules consist of

A

Serotonin, ADP, Ca2+

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5
Q

What is the role of phospholipids in the clotting cascade?

A

Activate coagulation factors

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6
Q

What is the role of GP Ia in the clotting cascade?

A

Binds collagen

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7
Q

What is the role of GP Ib in the clotting cascade?

A

Binds vWF

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8
Q

What is the role of GP IIb-IIIa in the clotting cascade?

A

Binds fibrinogen

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9
Q

What protein is the “added” protein in the extrinsic pathway?

A

Tissue factor

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10
Q

What factors are involved in the intrinsic pathway?

A

XII, XI, IX, VIII

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11
Q

What factors are involved in the extrinsic pathway?

A

TF, VII

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12
Q

What factors are involved in the final common pathway?

A

V, X, prothrombin/thrombin, fibrinogen/fibrin

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13
Q

Where does tissue factor come from?

A

Hidden cells exposed during injury
Microparticles floating in blood
Endothelial cells and monocytes

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14
Q

What activates factor VII?

A

Nothing, it’s just kinda there

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15
Q

What happens as soon as Xa is made?

A

Extrinsic pathway shuts down

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16
Q

What activates factor XI?

A

Thrombin

17
Q

What activates factor IX?

A

XIa

18
Q

What activates factor X?

A

TF/VIIa and IXa/VIIIa

19
Q

What activates prothrombin?

A

Xa

20
Q

What activates fibrinogen?

A

Thrombin

21
Q

What is the activating cofactor for Xa?

A

Va

22
Q

What activates plasminogen?

A

t-PA

23
Q

What does TFPI act upon?

A

TF/VIIa

24
Q

What does protein C act upon?

A

VIIIa and Va

25
Q

What does ATIII act upon?

A

TF/VIIa, IXa, XIa, Xa, and thrombin