Bleeding Disorders Flashcards
What are the characteristic hallmarks of platelet bleeding?
Superficial (skin)
Petichiae
Spontaneous
Mucousal
What are the characteristic hallmarks of factor bleeding?
Deep (joints)
Big bleeds
Trauma
What is the most common hereditary bleeding disorder?
Von Willebrand Disorder
What is the inheritance pattern of von Willebrand Disorder?
Autosomal dominant
What are the types of vWF disease and prevalence of each?
Type 1: Decreased vWF (70%)
Type 2: Abnormal vWF (25%)
Type 3: Absent vWF (5%)
What are the symptoms of vWF?
Mucosal bleeding (after dental surgery) Deep joint bleeding when severe
What are the following tests like in vW Disease? Bleeding time: PTT: INR: vWF level: Platelet aggregation:
Bleeding time: Prolonged PTT: prolonged INR: Normal vWF level: Decreased (normal in type 2) Platelet aggregation studies: abnormal
How do you treat VWD?
DDAVP, Cryoprecipitate, factor VIII
What does DDAVP do for vW disease?
Releases vWF from stores
What is the downside to long term factor VIII use for vWD?
Works less and less well over time because antibodies will be made against it
What is the inheritance pattern of Hemophilia?
X linked recessive (in most cases)
What is the most common factor deficiency?
Hemophilia A
What is the factor deficient in Hemophilia A?
Factor VIII
What does hemophilia A symptoms look like?
Deep joint bleeding, prolonged dental work bleeding
What do the following tests look like in Hemophilia A? INR: TT: Platelet count: Bleeding time: PTT: Factor VIII assays: DNA studies:
INR: normal TT:normal Platelet count: normal Bleeding time: normal PTT: prolonged Factor VIII assays: abnormal DNA studies: abnormal
