Principles of Drug Therapy

Question 1

Pharmacology? Drugs?

Answer 1

Study of drugs and their interactions with living systems

Any chemical that can affect living processes

Question 2

Clinical pharmacology? Therapeutics?

Answer 2

Study of drugs in humans

Use of drugs to diagnose, prevent, or tease disease or to prevent pregnancy. The medical use of drugs.

Question 3

Ideal drug?

Answer 3

Effectiveness, safety, seletivity. Reversible action, predictability, ease of administration, freedom from interactions, low cost, chemical stability, simple generic name. NO DRUG IS IDEAL

Question 4

Factors that determine the intensity of drug responses?

Answer 4

Administation, pharmacokinetics, pharmacodynamics

Question 5

Pharmacokinetics?Pharmacodynamics?

Answer 5

Pharmacokinetics is the movement of drugs, the way they move through the body, how it’s absorbed, distributed, metabolized by the liver, and excreted by the kidneys.
Pharmacodynamics is the impact of the drugs on the body.

Question 6

Controlled substance act of 1970

Answer 6

Class 1: high abuse potential, not currently used for treatment: Heroin, LSD
Class 2: High abuse potential with med uses: morphine, demerol
Class 3: Less abuse such ah lortab
Class 4: Low abuse such as Librium
Class 5: Limited abuse such as Lomotil

Question 7

Stages of new drug development

Answer 7

Preclinical testing

Clinical testing

Question 8

Clinical testing?

Answer 8

Phase 1: Evaluating the drug’s metabolism, pharmacokinetics, biologic effects
Phase 2: Therapeutic effectiveness
Phase 3: Safety
Phase 4: Post-marketing surveillance

Question 9

Chemical drug name

Answer 9

Description of its composition and molecular structure

Question 10

Generic drug name

Answer 10

Name given by the manufacturer who first develops the drug with approval by USAN council. Only one generic name, lower case

Question 11

Trade/brand drug name

Answer 11

Name under which a manufacturer markets a drug. Followed with R in a circle, capitalized

Question 12

Classifications of drugs?

Answer 12

Therapeutic class: the therapy that the drug performs.
Pharmacologic class: the drugs mechanism of actions.
Drug may belong to more than one class.

Question 13

OTC drugs

Answer 13

Purchased without a prescription. Label must contain plain language, user-friendly format, type large enough to read.
The type includes active ingredients, uses, warnings, directions, inactive ingredients.