Principles of biochemistry - Concepts Flashcards
Cellular Foundations
Chemical Foundations
Physical Foundations
Genetic Foundations
Evolutionary Foundations
Weak Interactions in Aqueous Systems
Ionization of Water, Weak Acids, and Weak Bases
Buffering against pH Changes in Biological Systems
Water as a Reactant
Amino Acids
Peptides and Proteins
Working with Proteins
The Structure of Proteins: Primary Structure
Overview of Protein Structure
Protein Secondary Structure
Protein Tertiary Structure
Protein Quaternary Structures
Protein Denaturation and Folding
Reversible Binding of a Protein to a Ligand: Oxygen-Binding Proteins
Complementary Interactions between Proteins and Ligands: The Immune System and Immunoglobulins
Protein Interactions Modulated by Chemical Energy: Actin, Myosin, and Molecular Motors
An Introduction to Enzymes
How Enzymes Work
Enzyme Kinetics as an Approach to Understanding Mechanism
Examples of Enzymatic Reactions
Regulatory Enzymes
Monosaccharides and Disaccharides
Polysaccharides
Glycoconjugates: Proteoglycans, Glycoproteins, and Glycosphingolipids
Carbohydrates as Informational Molecules: The Sugar Code
Working with Carbohydrates
Nucleotides and Nucleic Acids: Some Basics
Nucleic Acid Structure
Nucleic Acid Chemistry
Other Functions of Nucleotides
Studying Genes and Their Products
Using DNA-Based Methods to Understand Protein Function
Genomics and the Human Story
Storage Lipids
Structural Lipids in Membranes
Lipids as Signals, Cofactors, and Pigments
Working with Lipids
The Composition and Architecture of Membranes
Membrane Dynamics
Solute Transport across Membranes
General Features of Signal Transduction
G Protein–Coupled Receptors and Second Messengers
Receptor Tyrosine Kinases
Receptor Guanylyl Cyclases, cGMP, and Protein Kinase G
Multivalent Adaptor Proteins and Membrane Rafts
Gated Ion Channels
Integrins: Bidirectional Cell Adhesion Receptors
Regulation of Transcription by Nuclear Hormone Receptors
Signaling in Microorganisms and Plants
Sensory Transduction in Vision, Olfaction, and Gustation
Regulation of the Cell Cycle by Protein Kinases
Oncogenes, Tumor Suppressor Genes, and Programmed Cell Death
Bioenergetics and Thermodynamics
Chemical Logic and Common Biochemical Reactions
Phosphoryl Group Transfers and ATP
Biological Oxidation-Reduction Reactions
Glycolysis
Feeder Pathways for Glycolysis
Fates of Pyruvate under Anaerobic Conditions: Fermentation
Gluconeogenesis
Pentose Phosphate Pathway of Glucose Oxidation
Regulation of Metabolic Pathways
Analysis of Metabolic Control
Coordinated Regulation of Glycolysis and Gluconeogenesis
The Metabolism of Glycogen in Animals
Coordinated Regulation of Glycogen Synthesis and Breakdown
Production of Acetyl-CoA (Activated Acetate)
Reactions of the Citric Acid Cycle
Regulation of the Citric Acid Cycle
The Glyoxylate Cycle
Digestion, Mobilization, and Transport of Fats
Oxidation of Fatty Acids
Ketone Bodies
Metabolic Fates of Amino Groups
Nitrogen Excretion and the Urea Cycle
Pathways of Amino Acid Degradation
Electron-Transfer Reactions
in Mitochondria
ATP Synthesis
Regulation of Oxidative Phosphorylation
Mitochondria in Thermogenesis, Steroid Synthesis, and Apoptosis
Mitochondrial Genes: Their Origin and the Effects of Mutations
General Features of Photophosphorylation
Light Absorption
The Central Photochemical Event: Light-Driven Electron Flow
ATP Synthesis by Photophosphorylation
The Evolution of Oxygenic Photosynthesis
Photosynthetic Carbohydrate Synthesis
Photorespiration and the C4 and CAM Pathways
Biosynthesis of Starch and Sucrose
Synthesis of Cell Wall Polysaccharides: Plant Cellulose and Bacterial Peptidoglycan
Integration of Carbohydrate Metabolism in the Plant Cell
Biosynthesis of Fatty Acids
and Eicosanoids
Biosynthesis of Triacylglycerols
Biosynthesis of Membrane Phospholipids
Cholesterol, Steroids, and Isoprenoids: Biosynthesis, Regulation and Transport
Overview of Nitrogen Metabolism
Biosynthesis of Amino Acids
Molecules Derived from Amino Acids
Biosynthesis and Degradation of Nucleotides
Hormones: Diverse Structures for Diverse Functions
Tissue-Specific Metabolism: The Division of Labor
Hormonal Regulation of Fuel Metabolism
Obesity and the Regulation of Body Mass
Obesity, the Metabolic Syndrome, and Type 2 Diabetes
Chromosomal Elements
DNA Supercoiling
The Structure of Chromosomes
DNA Replication
DNA Repair
DNA Recombination
DNA-Dependent Synthesis of RNA
RNA Processing
RNA-Dependent Synthesis of RNA and DNA
The Genetic Code
Protein Synthesis
Protein synthesis occurs in five stages:
Protein Targeting and Degradation
Principles of Gene Regulation
Regulation of Gene Expression in Bacteria
Regulation of Gene Expression in Eukaryotes