Principles of Anesthesia Quiz #1 Flashcards
What is the blood pressure goal for cardiac patients in OR regarding baseline vitals and blood pressure?
Goal is to stay within 10-20% of ischemic free range of baseline pressure
Which heart implant will indicate to you that you have a very sick ventricle?
AICD, do not over load patient with fluid.
When should a new MI case be cancelled with an elective procedure
Postpone elective non-cardiac procedures if MI < 1 month prior to procedure Wait 6 months after MI
List high risk cardiac surgical procedures
Emergent Procedures
Aortic/vascular procedures
Peripheral vascular
Prolonged procedures with blood loss/fluid shifts
List intermediate risk cardiac surgical procedure
Carotid endarterectomy
Head/neck procedures
intraperitoneal
intrathoracic
List low risk cardiac surgical procedures
Superficial
cataract
Breast
Endoscopic
List the two most important perioperative cardiac risk factors
Urgency of procedure (complications 2 to 5 times more likely) Operative site (major thoracic, abdominal, vascular)
Intraoperative hypotension can be related to what day of surgery drug?
ACEI
Possible cancellation of procedure if DBP > ___ with evidence of ___
110, organ damage
Changes in retinal vasculature ___ the severity and progression of arteriosclerosis and hypertensive damage in other organs
parallel
What is normal ejection fraction?
65%
List the two main coronary arteries
LMCA (left ventricle) and RCA (SA node, AV node, PDA)
MR AS Systolic
Sound is restricted forward flow
MS AR Diastolic
Sound is unrestricted backward flow
What is the conduction rate of the SA node
100-110
Vagal tone brings the resting heart rate to about ___. Located in the junction of the ___ and ___.
60-80 bpm, RA, SVC
What carries electrical impulses to the LA
Bachmann’s Bundle
What is the intrinsic rate of the AV node
40-60 bpm
For leads I, V1, and V6, name differences in left and right bundle blocks.
Lead I - left rabbit ear, right biphasic
Lead V1 - left downward, right rabbit
Lead V6 - left upward, right biphasic
What has the fastest conduction velocities in the heart?
Purkinje Fibers
List responses of the sympathetic nervous system
Acceleratory response Norepinephrine Increase heart rate Increase force of contraction Increase conductivity Peripheral vasoconstriction Innervates all chambers of heart
List parasympathetic responses
Inhibitory response Acetylcholine Decreased heart rate Mild decrease in force of contraction Slows conduction through AVN Fibers exist in atria and ventricles (pronounced effects on atria, minimal effects on ventricles)
What is the equation of Coronary Vessel Perfusion
CPP = DBP - PAWP
Greatest during diastole when ventricle is relaxed, the wall is slightly softer, and blood flow is generous
What drug relaxes the heart wall allowing increased blood flow?
Nitro
What actions supply the heart?
Heart rate Perfusion pressure O2 content LVEDP CAD O2 extraction
What are the demands of the heart?
Heart rate Cardiac output PCWP (LAP) Systolic blood pressure Preload/Afterload/Contractility
Discuss the increase in heart rate and coronary perfusion
As heart rate increases, there is less time for coronary blood flow and perfusion. Systolic contraction pressures also occlude blood flow by applying pressure (10mmHg to 120mmHg). The subendocardium of the LV is most vulnerable.
___ is the biggest indicator of CAD.
Unstable angina. Poorly controlled by medications at this point, and carries a significant risk of MI
When damage to the heart’s endothemlium occurs, it produces less ___ and less ___
NO, Prostacyclin
“Critical stenosis” is a ___ decrease in diameter of a large distributing artery.
75%
What are goals for treatment of CAD
Restore normal coronary perfusion
Normalize O2 supply/demand ratio
Stent/CABG/Interventions
Antianginals/BB/CCB/Nitrodilators
What are pharmacological treatments for stable angina pectoris
Aspirin, plavix, beta blockers, CCB, nitrates, ACEI, risk reduction
Define unstable angina
Rest angina >20 minutes, often due to acute event i.e. rupture of small plaque
Ischemic heart disease, discuss
caused by supply/demand imbalance
Unstable angina - No damage or biomarker release
Non STEMI - Positive necrosis and biomarker release
STEMI - Biomarker release and ST changes
Discuss the four laboratory biomarkers for myocardial infarction (injury)
CK - simple, fast, skeletal muscle not specific to myocardial injury
CK-MB - Cardiac muscle, 3-4 hours post injury, peaks 24 hr, normal 36hr
Troponins - Gold standard, 3-12 hr post MI, elevated 5-10 days for trop I, 2 wks for trop II
BNP - heart failure marker
Insufficient blood supply to the myocardium results in:
Ischemia
Injury
Infarct
Depends on length of time blood supply is inefficient, degree of insufficiency, availability of collateral circulation
Ischemia increased by ___% in patients whose heart rate is >99 bpm preop
40
Most ischemic episodes are r/t ___
Hemodynamic instability
What medications do you avoid with ischemia?
Inotropes - increased contractility = increased demand = ischemia
What identifies ischemia intraoperatively?
ST segment depression of greater than 1 mm provides evidence of ischemia
List interventions for myocardial ischemia
Anesthesia Nitrates Beta blockers Calcium channel blockers Increased perfusion pressure Positive inotropes Initiate CPB, cardioplegia for protection, revascularize IABP