Primary Sclerosing Cholangitis Flashcards
1
Q
def
A
chronic progressive cholestasis with bile duct inflammation and strictures
2
Q
what is cholestasis
A
obstruction of bile flow from the liver to the duodenum
3
Q
aetiology
A
unknown
4
Q
what is PSC associated with
A
1 males
2 IBD
-especially UC (present in about 70%)
5
Q
epi
A
25-40yrs
6
Q
history
A
1 may be asymptomatic, an incidental finding after PERSISTANTLY high alkphos
2 intermittant pruritis, RUQ pain, fatigue
3 history of UC
7
Q
examination
A
1 often no signs
2 jaundice
3 hepatosplenomegaly
8
Q
investigations
A
1 bloods -LFTs (high alkphos, high GGT) 2 serology -AMA negative -ANCA/ANA may be positive 3 ERCP -distinguishes small + large duct disease
9
Q
what distinguishes PBC and PSC
A
PBC is AMA positive
PSC is AMA negative
10
Q
what Igs are raised in PSC
A
igG in children
igM in adults
11
Q
what is the use of liver biopsy in PSC
A
confirms diagnosis + stages disease
