Primary bone tumours Flashcards

1
Q

What are the benign bone tumours?

A
Osteochondroma
Osteoma
Osteoid osteoma
Osteoblastoma
Chondroma
Giant cell tumour
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2
Q

What is the most common benign tumour?

A

osteochondroma

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3
Q

Where does the tumour occur in osteochondroma?

A

metaphysis of long bones

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4
Q

Characteristics of osteochondroma?

A

growths laterally out of growth plate and is covered by cartilaginous cap

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5
Q

Where does an osteoma occur?

A

surface of facial bones

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6
Q

What is osteoma associated wtih?

A

gardner syndrome

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7
Q

Where does osteoid osteoma occur?

A

cortex of long bones

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8
Q

which cell causes the tumour in osteoid osteoma?

A

osteoblasts

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9
Q

presentation of osteoid osteoma?

A

Presents as bone pain that is worse at night and relieved the NSAIDS
Mass will be <2cm with radiolucent osteoid core

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10
Q

Where does an osteoblastoma occur?

A

vertebra

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11
Q

presentation of osteoblastoma?

A

bone pain that is worse at night but does not respond to NSAIDs
>2cm

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12
Q

Where does a chrondroma occur?

A

medulla of small bones in hands and feet

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13
Q

what is a chondroma?

A

a benign tumour of cartilage

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14
Q

Where does a giant cell tumour occur?

A

in the epiphysis of long bones (often knee)

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15
Q

appearance of giant cell tumour on xray?

A

soap bubble

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16
Q

pathophys of giant cell tumour?

A

mononuclear cells express RANKL and reactivate multinucleated giant cells (osteoclast like)

17
Q

What are the primary metastatic bone tumours?

A

osteosarcoma
Chondrosarcoma
Ewing sarcoma

18
Q

Is osteosarcoma more common in the young or old?

A

Young (males)

19
Q

where does osteosarcoma occur?

A

Metaphysis of long bones (often in knee region)

20
Q

Osteosarcoma histology

A

Pleomorphic osteoid-producing cells (malignant osteoblasts)

21
Q

Osteosarcoma xray findings

A

codman triangle and sunburst pattern on xray

22
Q

osteosarcoma presentation

A

painful enlarging mass

23
Q

Location of chondrosarcoma

A

Medulla of pelvis, proximal femur and humerus

24
Q

What is a chondrosarcoma?

A

tumour of malignant chondrocytes

25
Q

Who most commonly gets ewing sarcoma?

A

Caucasian boys under 15

26
Q

Where does ewing sarcoma occur?

A

Diaphysis of long bones (femur), pelvic flat bones

27
Q

ewing sarcoma histology?

A

anaplastic smallblue cells (resemble lymphocytes)

28
Q

Which fusion protein is present in ewing sarcoma?

A

t(11:22) - EWS-FLII

29
Q

What will you see on xray of Ewing sarcoma?

A

onion skin periosteal reaction in bone