Primary Biliary Cirrhosis Flashcards
1
Q
What is the presentation of PBC?
A
Fatigue
Pruritis
GI disturbance and abdominal pain
Jaundice
Pale stools
Xanthoma and Xanthelasma
Signs of cirrhosis and failure (ascites, splenomegaly, spider naevi etc)
2
Q
What age group and sex typically present with PBC?
A
Middle aged woman
3
Q
What other conditions are associated with PBC?
A
Autoimmune (thyroid, coeliac)
Rheumatoid conditions (arthritis etc.)
4
Q
How is PBC diagnosed?
A
ALP raised (as PBC causes cholestasis)
Raised bilirubin in later disease
Autoantibodies (AMA)
Raised ESR/CRP
Raised IgM
Liver biopsy
5
Q
What is the treatment of PBC?
A
Ursodeoxycholic acid
Colestyramine
Liver transplant
Immunosuppression (steroids)
6
Q
What are the complex of PBC?
A
Liver cirrhosis
Portal hypertension
