Non-Alcoholic Fatty Liver Disease

Question 1

What are the 4 stages of NAFLD?

Answer 1

1. NAFLD
2. Non-Alcoholic steatohepatitis (NASH)
3. Fibrosis
4. Cirrhosis

Question 2

What are the risk factors for NAFLD?

Answer 2

Same as diabetes and CVD

Obesity 
Poor diet
Little exercise 
T2DM
High cholesterol 
Middle age onwards 
Smoking 
High BP

Question 3

What investigations can be done for NAFLD?

Answer 3

US liver
Hep B and C serology
Autoantibodies (autoimmune hep, PBC, PSC)
Immunoglobulins (autoimmune hep, PBC)
Ceruloplasmin (Wilson’s)
A1AT (deficit)
Ferritin and transferrin (haemochromatosis)

Question 4

What diagnosis can US confirm in NAFLD?

Answer 4

Hepatic steatosis (fatty liver)

Question 5

What is the management of NAFLD?

Answer 5

Weight loss

Exercise

Stop smoking

Control of diabetes, BP and cholesterol

Avoid alcohol