Prilocaine

Question 1

What are the pharmacological properties of prilocaine?

Answer 1

• slightly lower onset than lignocaine

- less vasodilatory, distributed more rapidly, larger volume of distribution

Question 2

What is the metabolism of prilocaine?

Answer 2

By-product of metabolism (methaemoglobin) can exert effects on tissues in large doses

Question 3

What is the elimination half life of prilocaine?

Answer 3

Highest clearance of all amide- rapid metabolism in the liver accounts for this, additional clearance in lungs and kidneys

Question 4

What is the duration of action for prilocaine?

Answer 4

• -40-90 minutes pulp
• -150-210 minutes soft tissue
• with felypressin

Question 5

What are the preparations and proprietary names of prilocaine?

Answer 5

• 3% Prilocaine HCl with felypressin (0.03 IU/mL) Citanest ® with octapressin
• 4% Prilocaine HCl only Citanest ® 15
• 3% Prilocaine HCl with adrenaline (1: 300 000) Citanest ® 30 with adrenaline

Question 6

What is the dosages for prilocaine?

Answer 6

Maximum recommended dosage 9.0mg/kg, Absolute max (600 mg adult) 3% Prilocaine HCl with felypressin (0.03 IU/mL) Citanest ® with octapressin

Question 7

What are the indications for prilocaine?

Answer 7

When adrenaline is to be avoided.

Question 8

When is prilocaine contraindicated?

Answer 8

Coronary Artery conditions

Renal Impairment