Prev Med Flashcards
what guidelines will be tested
USPSTF, they are the most reliable preventative medicine guidelines, and the standard of care
What guides you choice in choosing a test
mortality benefit
Most important preventative medicine question:
Which cancer screening method lowers mortality the most? (which of the following is most likely to benefit the patient?)
mammography screening above age 50
Breast Cancer
Age to start mammography canbe controversial (40-50), but the age of maximum benefit is clear
> 50
Breast Cancer
screening overview
mammography should be done starting at age 40 to 50every 2 years. the reduction is mortality is greated above age 50.screening can stop at age 75
on average you will detect 10 cases of breates cancer by screening 1000 women above age 50, but you will detect only 2 cancers by screening 1000 women between the ages of 40 and 49.
the MRI, CT, andUS do not yet have a clear place in terms of screening for breast cancer.
breast self examination
is the wrong answer, although it may seem to benefit there is no proof
Breast Cancer
selective estrogen receptor modulators (SERMs)
tamoxifen, raloxifene
result in a 50 to 66% reduction in breast cancer when compared with placebo
greatest benefitis is in those with 2 first-degree relatives with breat cancer (mother or sister).
Breast Cancer
aromatase inhibitors
useful in preventingmetastases in those with provenbreast cancer butthey are not proven to bneeift those who are asymptomatic
Breast Cancer
Her/Neu2
gues the use of trastuzumab, which bocksthereceptor inthosewith ptovencncer
Breast Cancer
BRCA
associated with increased risk of breast and ovariancancer. however, this does not mean it is clearly bneeficial screening test. the missing piece is: what to do when th epatient is positive for BRCA? this is not clear. the only truly unambiguous statement about BRCA testing is that a psotivie test means on increased risk of cancer
management remains undetermined
when BRCA is positive
offering prophylactic bilateral mastectomy is the wrong answer
Cervical Cancer Screening
the first pap smear is done at age 21. pap every 3 years ages 21-30. pap smear devinitely lowers mortality. bc htere ar enoly 7000-10000 cases of cerical cancer a year, but 185000 cases of breast cancer, pap smear is not nearly as beneficial as mammoraphy.pap semar is done every 3 years. papillomavirus vaccine is routine for all women between the ages of 11 and 26. combined pap and hpv testing at ages 30 to 65 stretches the interval to 5 years
pap smear is done from
21 to 65 years of age
adding hpv testing to pap increases interval to
5 years
chlamydia screen women
15-25 years old
Colon Cancer Screening
the lifetime risk of colon cancer for an american is 6-8%. each year 50000 people die of colon cancer in the us.95% of these deaths are preventable with screening
Colonscopy
every 10 years after age 50
virtual colonoscopy
misses cancers in polyps less than 0.5 cm
capsule endoscopy
detects small bowel bleeding, not a colon cancer cancer screening method
dre
not proven to lower mortality in any disease, always a wrong choice
Prostate Cancer Screening
unfortunately ther is no clearly beneficial test to lower mortality in prostate cancer screening. neither the prostate specific antigen nor the digital rectal exam has proven sufficiently sensitive or specific to lower mortality. althouth PSA does detect prostate cancer, the lesions detected are most often not ones that need treatment. of patients with prostate cancer, 25% have a normal PSA, and 25% of those with an elevated PSA do not have cancer
if the question asks mortality nefit for PSA
say no